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TAK1(Thr184 + Thr187) Antibody

TAK1(Thr184 + Thr187) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameTAK1(Thr184 + Thr187) Antibody
Also known asTAK1(Thr184 + Thr187) Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenTAK1 Thr184 + Thr187
SpecificityThis is a highly specific antibody against TAK1 Thr184 + Thr187
Modification(s)Phosphorylation
Modification site(s)Thr184 + Thr187
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range170-192/605
SourceKLH conjugated synthetic phosphopeptide derived from human TAK1 around the phosphorylation site of Thr184/187
Gene ID number6885
Swiss ProtO43318
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), Ceramides are also able to activate MAP3K7/TAK1, In osmotic stress signaling, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7, MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis, Mediates signal transduction of TRAF6, Once activated, Plays an important role in the cascades of cellular responses evoked by changes in the environment, Promotes TRIM5 capsid-specific restriction activity, TGFB-related factors like BMP2 and BMP4, These MAP2Ks in turn activate p38 MAPKs, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, but not that of NF-kappa-B, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK), plays a major role in the activation of MAPK8/JNK1, toll-like receptors (TLR), transforming growth factor-beta (TGFB), tumor necrosis factor receptor CD40 and B-cell receptor (BCR), various cytokines including interleukin-1 (IL-1), while nuclear factor-kappa B is activated by IKK, Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names MAP3K7, MEKK7, Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1, TGF1a, Transforming growth factor-beta-activated kinase 1, TAK1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetTAK1(Thr184 + Thr187)
Short nameTAK1(Thr184 + Thr187) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameTAK1(Thr184 and Thr187) (Antibody to)
Alternative techniqueantibodies
Identity 6859
Gene MAP3K7
Long gene name mitogen-activated protein kinase kinase kinase 7
Synonyms gene TAK1
Synonyms MEKK7
Synonyms name TGF-beta activated kinase 1
Locus 6q15
Discovery year 1998-05-22
GenBank acession AB009356
Entrez gene record 6885
Pubmed identfication 9466656
RefSeq identity NM_145331
Classification Mitogen-activated protein kinase kinase kinases
Havana BLAST/BLAT OTTHUMG00000015217
Locus Specific Databases The Globin Gene Server

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