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Tap1 Antibody

Tap1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameTap1 Primary Polyclonal Antibody
Also known asTap1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenTap1
SpecificityThis is a highly specific antibody against Tap1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range525-575/808
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Tap1/ABCB2
Gene ID number6890
Swiss ProtQ03518
Tested Applications FCM, IF(ICC), IF(IHC-P), IHC-P, WB
Recommended dilutions FCM(1:20-100), IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Also acts as a molecular scaffold for the final stage of MHC class I folding, Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-1 protein, Inhibited by human adenovirus E3-19K glycoprotein, Inhibited by human cytomegalovirus US6 glycoprotein, Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, Nascent MHC class I molecules associate with TAP via tapasin, namely the binding of peptide, preventing MHC class I/TAP association, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules, which binds the TAP complex and acts as a tapasin inhibitor, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding, which blocks the peptide-binding site of TAP, Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ABC17, ABCB2, ATP-binding cassette sub-family B member 2, Antigen peptide transporter 1, D6S114E, PSF-1, PSF1, Peptide supply factor 1, Peptide transporter PSF1, Peptide transporter TAP1, Peptide transporter involved in antigen processing 1, RING4, Really interesting new gene 4 protein, TAP1, TAP1*12N, TAP1N, Y3, APT1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetTap1
Short nameTap1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name adenosine triphosphate-binding cassette, sub-family B (multi-drug-resistant/TAP) (Antibody to), transporter 1
Alternative techniqueantibodies
Identity 39758
Gene PSMB8-AS1
Long gene name PSMB8 antisense RNA 1 (head to head)
Synonyms gene TAPSAR1
Synonyms gene name TAP1 and PSMB8 antisense RNA 1
Synonyms XXbac-BPG246D15, 8 TAP1-AS1
Locus 6p21, 32
Discovery year 2013-07-25
Entrez gene record 100507463
RefSeq identity NR_037173
Havana BLAST/BLAT OTTHUMG00000140123

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