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TERF2IP (1664CT564.52.88) Monoclonal Antibody

TERF2IP (1664CT564.52.88) Monoclonal Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name52, 88) Monoclonal Antibody, TERF2IP (1664CT564
Also known as52, 88) Monoclonal Antibody, TERF2IP (1664CT564
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenTERF2IP
SpecificityThis is a highly specific antibody against TERF2IP
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number1664CT564, 52, 88
SourceThis TERF2IP antibody is generated from a mouse immunized with a recombinant protein from human TERF2IP
Gene ID number54386
Swiss ProtQ9NYB0
Tested ApplicationsIHC-P
Recommended dilutionsIHC-P(1:25)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2, In contrast to other components of the shelterin complex, Independently of its function in telomeres, Instead, Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome), When cytoplasmic, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), leading to activate expression of NF-kappa-B target genes, which can affect telomere length, Acts both as a regulator of telomere function and as a transcription regulator
Purification methodPurified by Protein G
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DRIP5, Dopamine receptor-interacting protein 5, PP8000, RAP1 homolog, Repressor/activator protein 1 homolog, TERF2-interacting telomeric protein 1, TERF2IP, TRF2-interacting telomeric protein 1, Telomeric repeat-binding factor 2-interacting protein 1, hRap1, RAP1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target52, 88) Monoclonal, TERF2IP (1664CT564
Short name52, 88) Monoclonal Antibody, TERF2IP (1664CT564
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name52, 88) monoclonal (Antibody to), TERF2IP (1664CT564
Alternative techniqueantibodies
Identity 19246
Gene TERF2IP
Long gene name TERF2 interacting protein
Synonyms gene name interacting protein , telomeric repeat binding factor 2
Synonyms RAP1
Locus 16q23, 1
Discovery year 2002-09-18
GenBank acession AK000669
Entrez gene record 54386
Pubmed identfication 10850490
RefSeq identity NM_018975
Classification Shelterin complex
Havana BLAST/BLAT OTTHUMG00000177136
Locus Specific Databases LRG_1084

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