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TGF beta R2 Antibody, ALEXA FLUOR 350

TGF beta R2 Antibody, ALEXA FLUOR 350 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 350 Conjugated, TGF beta R2 Polyclonal Antibody
Also known asAnti-TGF beta Receptor II PAb ALEXA FLUOR 350
CategoryConjugated Primary Antibodies
Conjugated with 350, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenTGF beta Receptor II
SpecificityThis is a highly specific antibody against TGF beta Receptor II
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range230-280/567
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TGF beta R2
Gene ID Number7048
Swiss ProtP37173
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4, Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways, TGFB2 and TGFB3, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, TGFBR1, The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes, The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2, This constitutes the canonical SMAD-dependent TGF-beta signaling cascade, Transduces the TGFB1, control of mesenchymal cell proliferation and differentiation, extracellular matrix production, immunosuppression and carcinogenesis, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, wound healing, Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission343nm/442nm
Synonyms FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGF-beta receptor type II, TGF-beta receptor type-2, TGF-beta type II receptor, TGFBR2, TGFR-2, TGFbeta-RII, TbetaR-II, Transforming growth factor-beta receptor type II, AAT3
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 350, Alexa Fluor
Gene targetTGF beta R2
Short nameTGF beta R2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 350
Alternative name ALEXA FLUOR 350, TGF b R2 (Antibody to)
Alternative techniqueantibodies

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