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TGF beta R2 Antibody, Biotin Conjugated

TGF beta R2 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, TGF beta R2 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenTGF beta Receptor II
SpecificityThis is a highly specific antibody against TGF beta Receptor II
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range230-280/567
Subcellular locationCytoplasm
SourceKLH conjugated synthetic peptide derived from human TGF beta R2
Gene ID number7048
Swiss ProtP37173
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4, Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways, TGFB2 and TGFB3, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, TGFBR1, The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes, The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2, This constitutes the canonical SMAD-dependent TGF-beta signaling cascade, Transduces the TGFB1, control of mesenchymal cell proliferation and differentiation, extracellular matrix production, immunosuppression and carcinogenesis, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, wound healing, Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGF-beta receptor type II, TGF-beta receptor type-2, TGF-beta type II receptor, TGFBR2, TGFR-2, TGFbeta-RII, TbetaR-II, Transforming growth factor-beta receptor type II, AAT3
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetTGF beta R2 Conjugated
Short name Conjugated, TGF beta R2 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, TGF b R2 (Antibody to)
Alternative techniqueantibodies

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