| Long name | ALEXA FLUOR 488 Conjugated, Thyroid Hormone Receptor beta Antibody |
| Also known as | Anti-THRB1/Thyroid Hormone Receptor beta PAb ALEXA FLUOR 488 |
| Category | Conjugated Primary Antibodies |
| Conjugated with | 488, ALEXA FLUOR® |
| Host Organism | Rabbit (Oryctolagus cuniculus) |
| Target Antigen | THRB1/Thyroid Hormone Receptor beta |
| Specificity | This is a highly specific antibody against THRB1/Thyroid Hormone Receptor beta |
| Modification | Unmodified |
| Modification Site | None |
| Clonality | Polyclonal |
| Clone | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Thyroid Hormone Receptor beta |
| Gene ID Number | 7068 |
| Tested applications | IF(IHC-P) |
| Recommended dilutions | IF(IHC-P)(1:50-200) |
| Crossreactivity | Mouse, Rat, Human |
| Cross-reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen | Defects in the receptor result in generalized thyroid hormone resistance (GTHR), GTHR is transmitted as an autosomal dominant trait, GTHR patients also have high levels of circulating thyroid hormones (T3-T4), It is composed of three domains: a modulating N-terminal domain, The disease is characterized by goiter, Thyroid hormone receptor b2 (TRb2) is a high affinity receptor for triiodothyronine which belongs to the nuclear hormone receptor family and the NR1 subfamily, a DNA-binding domain and a C-terminal steroid-binding domain, abnormal growth and bone maturation, abnormal mental functions, but an autosomal recessive form also exists, increased susceptibility to infections, tachycardia and deafness, with normal or slightly elevated thyroid stimulating hormone, Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3) |
| Purification | Purified by Protein A |
| Storage conditions | 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission | 499nm/519nm |
| Synonyms | THRB1 THRB2 NR1A2 THR1 ERBA-BETA GRTH |
| Properties | ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Thyroid Hormone Receptor beta Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation | Alexa Fluor |
| Description | FSH comprise the , Human recombinant LHRG and GHRH are produced in E, The glands that secrete Luteinizing hormones LHRG and LH, The term growth hormone releasing hormone GHRH is sometimes extended to include chemicals produced by cells that affect the same cell (autocrine , coli or in yeast cells, Hormone releasing factors and releasing hormones are , endocrine signaling system, glands , in , intracrine signaling) or nearby cells (paracrine signaling), multicellular organisms, or , produced by , signaling molecules |
| Gene target | Thyroid Hormone Receptor beta |
| Short name | Thyroid Hormone Receptor beta Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Label | ALEXA FLUOR 488 |
| Alternative name | ALEXA FLUOR 488, Thyroid Hormone Receptor b (Antibody to) |
| Alternative technique | antibodies |
| Identity | 11799 |
| Gene | THRB |
| Long gene name | thyroid hormone receptor beta |
| Synonyms gene | ERBA2 PRTH |
| Synonyms gene name | avian) thyroid hormone receptor, beta , beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2) pituitary resistance to thyroid hormone thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, thyroid hormone receptor |
| Synonyms name | avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2 oncogene ERBA2 generalized resistance to thyroid hormone thyroid hormone receptor beta 1 |
| Locus | 3p24, 2 |
| Discovery year | 1988-08-31 |
| Entrez gene record | 7068 |
| Pubmed identfication | 1973914 8040303 |
| RefSeq identity | NM_000461 |
| Classification | Nuclear hormone receptors |
| Havana BLAST/BLAT | OTTHUMG00000130478 |
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