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TIE2/CD202b Antibody

TIE2/CD202b Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameTIE2/CD202b Primary Polyclonal Antibody
Also known asTIE2/CD202b PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenTIE2/CD202b
SpecificityThis is a highly specific antibody against TIE2/CD202b
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range450-500/1124
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Tie2
Gene ID number7010
Swiss ProtQ02763
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen ANGPT1 oligomers recruit TEK to cell-cell contacts, ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors, ANGPT2 and ANGPT4 and regulates angiogenesis, ANGT1 recruits TEK to contacts with the extracellular matrix, After birth, GRB14, GRB7, Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels, In migrating endothelial cells that lack cell-cell adhesions, In quiescent vessels, Inhibits angiogenesis and promotes vascular stability in quiescent vessels, PIK3R1, Required for normal angiogenesis and heart development during embryogenesis, Required for post-natal hematopoiesis, SHC1 and TIE1, Signaling is also modulated by formation of heterodimers with TIE1, Signaling is modulated by ANGPT2 that has lower affinity for TEK, TEK phosphorylates DOK2, The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins, activates or inhibits angiogenesis, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, adhesion and cell spreading, and by proteolytic processing that gives rise to a soluble TEK extracellular domain, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades, and ultimately to the stimulation of sprouting angiogenesis, but also maintenance of vascular quiescence, but inhibits ANGPT1-mediated signaling by competing for the same binding site, can promote TEK autophosphorylation in the absence of ANGPT1, depending on the context, endothelial cell survival, forming complexes with TEK molecules from adjoining cells, leading to the formation of focal adhesion complexes, migration, proliferation, reorganization of the actin cytoskeleton, where endothelial cells have tight contacts, Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Angiopoietin-1 receptor, CD22B, Endothelial tyrosine kinase, TEK, TIE-2, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, VMCM, VMCM1, hTIE2, p14 TEK, TIE2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetTIE2/CD202b
Short nameTIE2/CD202b Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameTIE2/CD202b (Antibody to)
Alternative techniqueantibodies
Identity 11724
Gene TEK
Long gene name TEK receptor tyrosine kinase
Synonyms gene VMCM
Synonyms gene name endothelial , multiple cutaneous and mucosal TEK tyrosine kinase, venous malformations
Synonyms TIE2 TIE-2 VMCM1 CD202b
Locus 9p21, 2
Discovery year 1994-05-24
GenBank acession L06139
Entrez gene record 7010
Pubmed identfication 1312667 7833915
Classification Fibronectin type III domain containing CD molecules Immunoglobulin like domain containing Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000019712

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