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TIE2/CD202b Antibody, Biotin Conjugated

TIE2/CD202b Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, TIE2/CD202b Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenTIE2/CD202b
SpecificityThis is a highly specific antibody against TIE2/CD202b
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range450-500/1124
Subcellular locationExtracellular
SourceKLH conjugated synthetic peptide derived from human Tie2
Gene ID number7010
Swiss ProtQ02763
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background ANGPT1 oligomers recruit TEK to cell-cell contacts, ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors, ANGPT2 and ANGPT4 and regulates angiogenesis, ANGT1 recruits TEK to contacts with the extracellular matrix, After birth, GRB14, GRB7, Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels, In migrating endothelial cells that lack cell-cell adhesions, In quiescent vessels, Inhibits angiogenesis and promotes vascular stability in quiescent vessels, PIK3R1, Required for normal angiogenesis and heart development during embryogenesis, Required for post-natal hematopoiesis, SHC1 and TIE1, Signaling is also modulated by formation of heterodimers with TIE1, Signaling is modulated by ANGPT2 that has lower affinity for TEK, TEK phosphorylates DOK2, The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins, activates or inhibits angiogenesis, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, adhesion and cell spreading, and by proteolytic processing that gives rise to a soluble TEK extracellular domain, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades, and ultimately to the stimulation of sprouting angiogenesis, but also maintenance of vascular quiescence, but inhibits ANGPT1-mediated signaling by competing for the same binding site, can promote TEK autophosphorylation in the absence of ANGPT1, depending on the context, endothelial cell survival, forming complexes with TEK molecules from adjoining cells, leading to the formation of focal adhesion complexes, migration, proliferation, reorganization of the actin cytoskeleton, where endothelial cells have tight contacts, Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms TIE2 TIE-2 VMCM1 CD202b
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetTIE2/CD202b Conjugated
Short name Conjugated, TIE2/CD202b Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, TIE2/CD202b (Antibody to)
Alternative techniqueantibodies
Identity 11724
Gene TEK
Long gene name TEK receptor tyrosine kinase
Synonyms gene VMCM
Synonyms gene name endothelial , multiple cutaneous and mucosal TEK tyrosine kinase, venous malformations
Locus 9p21, 2
Discovery year 1994-05-24
GenBank acession L06139
Entrez gene record 7010
Pubmed identfication 1312667 7833915
Classification Fibronectin type III domain containing CD molecules Immunoglobulin like domain containing Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000019712

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