| Long name | Biotin Conjugated, TIRAP(Tyr86) Polyclonal Antibody |
| Category | Conjugated Primary Antibodies |
| Conjugation | Biotinylated |
| Host Organism | Rabbit (Oryctolagus cuniculus) |
| Target Antigen | TIRAP Tyr86 |
| Specificity | This is a highly specific antibody against TIRAP Tyr86 |
| Modification | Phosphorylation |
| Modification site | Tyr86 |
| Clonality | Polyclonal |
| Clone | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen_range | 70-95/221 |
| Source | KLH conjugated synthetic acetylpeptide derived from human TIRAP around phosphorylation site of Tyr86 [KD(p-Y)DV] |
| Gene ID number | 114609 |
| Swiss Prot | P58753 |
| Tested applications | IHC-P, WB |
| Recommended dilutions | IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity | Mouse, Human |
| Crossreactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background | Acts via IRAK2 and TRAF-6, MAPK1, MAPK3 and JNK, Positively regulates the production of TNF-alpha and interleukin-6, and resulting in cytokine secretion and the inflammatory response, leading to the activation of NF-kappa-B, Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission | N/A |
| Synonyms | Mal wyatt |
| Properties | Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target | TIRAP(Tyr86) Conjugated |
| Short name | Conjugated, TIRAP(Tyr86) Antibody |
| Technique | antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label | Biotin |
| Alternative name | biotinilated coupled, toll-interleukin 1 receptor (TIR) domain containing adaptor protein(Tyr86) (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | Plasma membranes, TIRAP and IDBG-642760 and ENSBTAG00000021504 and 531079, TIRAP and IDBG-75811 and ENSG00000150455 and 114609, Tirap and IDBG-148134 and ENSMUSG00000032041 and 117149, bridging, bridging and also this GO :0035662: Toll-like receptor 4 binding and also this GO :0035663: Toll-like receptor 2 binding and also this GO :0042803: protein homodimerization activity and also this GO :0046982: protein heterodimerization activity, bridging and molecular function this GO :0030890 and positive regulation of B cell proliferation and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032587 and ruffle membrane and cellular component this GO :0032648 and regulation of interferon-beta production and biological process this GO :0032735 and positive regulation of interleukin-12 production and biological process this GO :0032738 and positive regulation of interleukin-15 production and biological process this GO :0032757 and positive regulation of interleukin-8 production and biological process this GO :0032760 and positive regulation of tumor necrosis factor production and biological process this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034137 and positive regulation of toll-like receptor 2 signaling pathway and biological process this GO :0034141 and positive regulation of toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034145 and positive regulation of toll-like receptor 4 signaling pathway and biological process this GO :0035662 and Toll-like receptor 4 binding and molecular function this GO :0035663 and Toll-like receptor 2 binding and molecular function this GO :0035665 and TIRAP-dependent toll-like receptor 4 signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0044130 and negative regulation of growth of symbiont in host and biological process this GO :0045087 and innate immune response and biological process this GO :0045088 and regulation of innate immune response and biological process this GO :0045410 and positive regulation of interleukin-6 biosynthetic process and biological process this GO :0046330 and positive regulation of JNK cascade and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0050830 and defense response to Gram-positive bacterium and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0070935 and 3'-UTR-mediated mRNA stabilization and biological process this GO :0071221 and cellular response to bacterial lipopeptide and biological process this GO :0071223 and cellular response to lipoteichoic acid and biological process this GO :0090023 and positive regulation of neutrophil chemotaxis and biological process this GO :0090073 and positive regulation of protein homodimerization activity and biological process this GO :2000340 and positive regulation of chemokine (C-X-C motif) ligand 1 production and biological process this GO :2000343 and positive regulation of chemokine (C-X-C motif) ligand 2 production and biological process, phosphatidylinositol-4, this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0005080 and protein kinase C binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005546 and phosphatidylinositol-4, this GO :0005080: protein kinase C binding, this GO :0005080: protein kinase C binding and also this GO :0005515: protein binding and also this GO :0005546: phosphatidylinositol-4, this GO :0005515: protein binding, this GO :0005546: phosphatidylinositol-4, this GO :0030674: protein binding, this GO :0035662: Toll-like receptor 4 binding, this GO :0035663: Toll-like receptor 2 binding, this GO :0042803: protein homodimerization activity, this GO :0046982: protein heterodimerization activity, 5-bisphosphate binding, 5-bisphosphate binding and also this GO :0030674: protein binding, 5-bisphosphate binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006954 and inflammatory response and biological process this GO :0007165 and signal transduction and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007249 and I-kappaB kinase/NF-kappaB signaling and biological process this GO :0030099 and myeloid cell differentiation and biological process this GO :0030139 and endocytic vesicle and cellular component this GO :0030674 and protein binding, toll-interleukin 1 receptor (TIR) domain containing adaptor protein |
| Identity | 17192 |
| Gene | TIRAP |
| Long gene name | TIR domain containing adaptor protein |
| Synonyms gene name | Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein |
| Synonyms name | MyD88 adapter-like |
| Locus | 11q24, 2 |
| Discovery year | 2003-06-05 |
| GenBank acession | AF378129 |
| Entrez gene record | 114609 |
| Pubmed identfication | 11526399 11544529 |
| RefSeq identity | NM_148910 |
| Classification | TIR domain containing |
| Havana BLAST/BLAT | OTTHUMG00000140373 |
Technique
Supplier
Species
Label
Iso Type
Host
Tissue