| Long name | Cy3 Conjugated, TIRAP(Tyr86) Polyclonal Antibody |
| Category | Conjugated Primary Antibodies |
| Conjugation | cy3 conjugation kit |
| Host Organism | Rabbit (Oryctolagus cuniculus) |
| Target Antigen | TIRAP Tyr86 |
| Specificity | This is a highly specific antibody against TIRAP Tyr86 |
| Modification | Phosphorylation |
| Modification site | Tyr86 |
| Clonality | Polyclonal |
| Clone | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen_range | 70-95/221 |
| Source | KLH conjugated synthetic acetylpeptide derived from human TIRAP around phosphorylation site of Tyr86 [KD(p-Y)DV] |
| Gene ID number | 114609 |
| Swiss Prot | P58753 |
| Tested applications | IF(IHC-P) |
| Recommended dilutions | IF(IHC-P)(1:50-200) |
| Crossreactivity | Mouse, Human |
| Crossreactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background | Acts via IRAK2 and TRAF-6, MAPK1, MAPK3 and JNK, Positively regulates the production of TNF-alpha and interleukin-6, and resulting in cytokine secretion and the inflammatory response, leading to the activation of NF-kappa-B, Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission | 512, 550nm/570, 615nm |
| Synonyms | Mal wyatt |
| Properties | 1 of the TIRAP(Tyr86) Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target | TIRAP(Tyr86) Conjugated |
| Short name | Conjugated, TIRAP(Tyr86) Antibody |
| Technique | antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label | Cy3 |
| Alternative name | cyanine 3 coupled, toll-interleukin 1 receptor (TIR) domain containing adaptor protein(Tyr86) (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | Plasma membranes, TIRAP and IDBG-642760 and ENSBTAG00000021504 and 531079, TIRAP and IDBG-75811 and ENSG00000150455 and 114609, Tirap and IDBG-148134 and ENSMUSG00000032041 and 117149, bridging, bridging and also this GO :0035662: Toll-like receptor 4 binding and also this GO :0035663: Toll-like receptor 2 binding and also this GO :0042803: protein homodimerization activity and also this GO :0046982: protein heterodimerization activity, bridging and molecular function this GO :0030890 and positive regulation of B cell proliferation and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032587 and ruffle membrane and cellular component this GO :0032648 and regulation of interferon-beta production and biological process this GO :0032735 and positive regulation of interleukin-12 production and biological process this GO :0032738 and positive regulation of interleukin-15 production and biological process this GO :0032757 and positive regulation of interleukin-8 production and biological process this GO :0032760 and positive regulation of tumor necrosis factor production and biological process this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034137 and positive regulation of toll-like receptor 2 signaling pathway and biological process this GO :0034141 and positive regulation of toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034145 and positive regulation of toll-like receptor 4 signaling pathway and biological process this GO :0035662 and Toll-like receptor 4 binding and molecular function this GO :0035663 and Toll-like receptor 2 binding and molecular function this GO :0035665 and TIRAP-dependent toll-like receptor 4 signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0044130 and negative regulation of growth of symbiont in host and biological process this GO :0045087 and innate immune response and biological process this GO :0045088 and regulation of innate immune response and biological process this GO :0045410 and positive regulation of interleukin-6 biosynthetic process and biological process this GO :0046330 and positive regulation of JNK cascade and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0050830 and defense response to Gram-positive bacterium and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0070935 and 3'-UTR-mediated mRNA stabilization and biological process this GO :0071221 and cellular response to bacterial lipopeptide and biological process this GO :0071223 and cellular response to lipoteichoic acid and biological process this GO :0090023 and positive regulation of neutrophil chemotaxis and biological process this GO :0090073 and positive regulation of protein homodimerization activity and biological process this GO :2000340 and positive regulation of chemokine (C-X-C motif) ligand 1 production and biological process this GO :2000343 and positive regulation of chemokine (C-X-C motif) ligand 2 production and biological process, phosphatidylinositol-4, this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0005080 and protein kinase C binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005546 and phosphatidylinositol-4, this GO :0005080: protein kinase C binding, this GO :0005080: protein kinase C binding and also this GO :0005515: protein binding and also this GO :0005546: phosphatidylinositol-4, this GO :0005515: protein binding, this GO :0005546: phosphatidylinositol-4, this GO :0030674: protein binding, this GO :0035662: Toll-like receptor 4 binding, this GO :0035663: Toll-like receptor 2 binding, this GO :0042803: protein homodimerization activity, this GO :0046982: protein heterodimerization activity, 5-bisphosphate binding, 5-bisphosphate binding and also this GO :0030674: protein binding, 5-bisphosphate binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006954 and inflammatory response and biological process this GO :0007165 and signal transduction and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007249 and I-kappaB kinase/NF-kappaB signaling and biological process this GO :0030099 and myeloid cell differentiation and biological process this GO :0030139 and endocytic vesicle and cellular component this GO :0030674 and protein binding, toll-interleukin 1 receptor (TIR) domain containing adaptor protein |
| Identity | 17192 |
| Gene | TIRAP |
| Long gene name | TIR domain containing adaptor protein |
| Synonyms gene name | Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein |
| Synonyms name | MyD88 adapter-like |
| Locus | 11q24, 2 |
| Discovery year | 2003-06-05 |
| GenBank acession | AF378129 |
| Entrez gene record | 114609 |
| Pubmed identfication | 11526399 11544529 |
| RefSeq identity | NM_148910 |
| Classification | TIR domain containing |
| Havana BLAST/BLAT | OTTHUMG00000140373 |
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