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TOM1L1 Antibody

TOM1L1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameTOM1L1 Primary Polyclonal Antibody
Also known asTOM1L1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenTOM1L1
SpecificityThis is a highly specific antibody against TOM1L1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TOM1L1
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen As an interactor and a substrate of Src tyrosine kinases (SFK), Containing a GAT domain and a VHS domain, GAT domain of Tom1L1 binds ubiquitin, GRB2, It is suggested that Tom1L-1 functions as an anti-oncogene by inhibiting the formation of squamous cell carcinomas in skin, PI 3-kinase p85?and various signaling proteins when phosphorylated, Tom1L-1 interacts with Fyn, Tom1L-1 may act as an adapter protein involved in signaling pathways and may promote Fyn activation, Tom1L1 is considered a novel mechanism involved in negative regulation of SFK mitogenic and transforming signals, Tom1L1 modulates SFK partitioning at the plasma membrane and downregulates Src kinases in an endosomal-dependent manner, possibly by disrupting intramolecular SH3-dependent interactions, suggesting participation in the sorting of ubiquitinated proteins into MVBs, Tom1L-1 is a 476 amino acid Golgi apparatus protein belonging to the TOM1 family and is a member of the multivesicular body (MVB) sorting machinery
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names SRCASM, Src activating and signaling molecule, Src activating and signaling molecule protein, Src-activating and signaling molecule protein, TM1L1_HUMAN, TOM1 L1, TOM1 like protein 1, TOM1-like protein 1, TOM1L1, TOM1L1 protein, Target of Myb like protein 1, Target of Myb-like protein 1, Target of myb1 chicken homolog like 1, Target of myb1 chicken like 1, Target of myb1 like 1, 3, OK/KNS CL
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetTOM1L1
Short nameTOM1L1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameTOM1L1 (Antibody to)
Alternative techniqueantibodies
Identity 11983
Gene TOM1L1
Long gene name target of myb1 like 1 membrane trafficking protein
Synonyms gene name target of myb1 (chicken) homolog-like 1 target of myb1 (chicken)-like 1
Synonyms SRCASM
Locus 17q23, 2
Discovery year 1998-10-14
GenBank acession AJ010071
Entrez gene record 10040
Pubmed identfication 10329004 15611048 17977829
RefSeq identity NM_005486
Havana BLAST/BLAT OTTHUMG00000177816

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