| Long name | TRAF3 Primary Polyclonal Antibody |
| Also known as | TRAF3 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | TRAF3 |
| Specificity | This is a highly specific antibody against TRAF3 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 130-180/568 |
| Subcellular location | Cytoplasm |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TRAF3 |
| Gene ID number | 7187 |
| Swiss Prot | Q13114 |
| Tested Applications | FCM, IF(IHC-P), IHC-P, WB |
| Recommended dilutions | FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Down-regulates proteolytic processing of NFKB2, Inhibits TRAF2-mediated activation of NF-kappa-B, Inhibits activation of NF-kappa-B in response to LTBR stimulation, Is an essential constituent of several E3 ubiquitin-protein ligase complexes, May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins, Part of signaling pathways leading to the production of cytokines and interferon, Plays a role T-cell dependent immune responses, Plays a role in the regulation of antiviral responses, Promotes ubiquitination and proteasomal degradation of MAP3K14, Required for normal antibody isotype switching from IgM to IgG, and plays a central role in the regulation of B-cell survival, and thereby inhibits non-canonical activation of NF-kappa-B, Regulates pathways leading to the activation of NF-kappa-B and MAP kinases |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | CAP-1, CD40 receptor-associated factor 1, CD40-binding protein, CD40bp, CRAF1, IIAE5, LAP1, LMP1-associated protein 1, TNF receptor-associated factor 3, TRAF3, CAP1 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | TRAF3 |
| Short name | TRAF3 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | tumor necrosis factor receptor-associated factor 3 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | CAP-1 and CAP1 and CD40bp and CRAF1 and IIAE5 and LAP1, Plasma membranes, TRAF3 and IDBG-21240 and ENSG00000131323 and 7187, TRAF3 and IDBG-635183 and ENSBTAG00000013475 and 506182, Traf3 and IDBG-172558 and ENSMUSG00000021277 and 22031, thioesterase binding, this GO :0001817 and regulation of cytokine production and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0005164 and tumor necrosis factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005739 and mitochondrion and cellular component this GO :0005768 and endosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0008063 and Toll signaling pathway and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0009898 and cytoplasmic side of plasma membrane and cellular component this GO :0016567 and protein ubiquitination and biological process this GO :0016874 and ligase activity and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0030162 and regulation of proteolysis and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0031996 and thioesterase binding and molecular function this GO :0032088 and negative regulation of NF-kappaB transcription factor activity and biological process this GO :0032480 and negative regulation of type I interferon production and biological process this GO :0032648 and regulation of interferon-beta production and biological process this GO :0033209 and tumor necrosis factor-mediated signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0035631 and CD40 receptor complex and cellular component this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0050688 and regulation of defense response to virus and biological process, this GO :0004842: ubiquitin-protein transferase activity, this GO :0004842: ubiquitin-protein transferase activity and also this GO :0004871: signal transducer activity and also this GO :0005164: tumor necrosis factor receptor binding and also this GO :0005515: protein binding and also this GO :0008270: zinc ion binding and also this GO :0016874: ligase activity and also this GO :0019901: protein kinase binding and also this GO :0031625: ubiquitin protein ligase binding and also this GO :0031996: thioesterase binding, this GO :0004871: signal transducer activity, this GO :0005164: tumor necrosis factor receptor binding, this GO :0005515: protein binding, this GO :0008270: zinc ion binding, this GO :0016874: ligase activity, this GO :0019901: protein kinase binding, this GO :0031625: ubiquitin protein ligase binding, this GO :0031996: thioesterase binding, TNF receptor-associated factor 3 |
| Identity | 12033 |
| Gene | TRAF3 |
| Long gene name | TNF receptor associated factor 3 |
| Synonyms | CAP-1 CD40bp CRAF1 LAP1 |
| Locus | 14q32, 32 |
| Discovery year | 1998-05-05 |
| GenBank acession | U21092 |
| Entrez gene record | 7187 |
| Pubmed identfication | 7530216 7859281 |
| RefSeq identity | NM_145725 |
| Classification | Zinc fingers TNF receptor associated factors |
| Havana BLAST/BLAT | OTTHUMG00000171902 |
| Locus Specific Databases | LRG_229 |
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