| Long name | TRAF6 Primary Polyclonal Antibody |
| Also known as | TRAF6 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | TRAF6 |
| Specificity | This is a highly specific antibody against TRAF6 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 500-530/530 |
| Subcellular location | Nucleus, Cytoplasm |
| Source | KLH conjugated synthetic peptide derived from mouse TRAF6 |
| Gene ID number | 22034 |
| Swiss Prot | P70196 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | AKT1 and AKT2, Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (By similarity), IL-1 receptor and IL-17 receptor, IRAK1, Leads to the activation of NF-kappa-B and JUN, May be essential for the formation of functional osteoclasts, Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, Represses c-Myb-mediated transactivation, Seems to also play a role in dendritic cells (DCs) maturation and/or activation, Together with MAP3K8, and thus may play a role in the regulation of immunoglobulin production, in B-lymphocytes, in response to RANK-L stimulation, mediates CD40 signals that activate ERK in B-cells and macrophages, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, together with UBE2N and UBE2V1, E3 ubiquitin ligase that |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | 2310003F17Rik, C630032O20Rik, E3 ubiquitin-protein ligase TRAF6, TNF receptor-associated factor 6, Traf6, AI851288 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | TRAF6 |
| Short name | TRAF6 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | E3 ubiquitin protein ligase (Antibody to), tumor necrosis factor receptor-associated factor 6 |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046849 and bone remodeling and biological process this GO :0046872 and metal ion binding and molecular function this GO :0047485 and protein N-terminus binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048468 and cell development and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0048661 and positive regulation of smooth muscle cell proliferation and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0050870 and positive regulation of T cell activation and biological process this GO :0051023 and regulation of immunoglobulin secretion and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051403 and stress-activated MAPK cascade and biological process this GO :0051865 and protein autoubiquitination and biological process this GO :0070423 and nucleotide-binding oli this GO merization domain containing signaling pathway and biological process this GO :0070498 and interleukin-1-mediated signaling pathway and biological process this GO :0070534 and protein K63-linked ubiquitination and biological process this GO :0070555 and response to interleukin-1 and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :2000679 and positive regulation of transcription regulatory region DNA binding and biological process, E3 ubiquitin protein ligase, MGC:3310 and RNF85, TRAF6 and IDBG-40102 and ENSG00000175104 and 7189, TRAF6 and IDBG-636763 and ENSBTAG00000036009 and 539124, Traf6 and IDBG-193222 and ENSMUSG00000027164 and 22034, leucine rich repeat containing receptor signaling pathway and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0042088 and T-helper 1 type immune response and biological process this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0042475 and odontogenesis of dentin-containing tooth and biological process this GO :0042826 and histone deacetylase binding and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043011 and myeloid dendritic cell differentiation and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043234 and protein complex and cellular component this GO :0043422 and protein kinase B binding and molecular function this GO :0043507 and positive regulation of JUN kinase activity and biological process this GO :0045084 and positive regulation of interleukin-12 biosynthetic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045410 and positive regulation of interleukin-6 biosynthetic process and biological process this GO :0045453 and bone resorption and biological process this GO :0045672 and positive regulation of osteoclast differentiation and biological process this GO :0045892 and negative regulation of transcription, nuclei, protein N-terminus binding, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000187 and activation of MAPK activity and biological process this GO :0000209 and protein polyubiquitination and biological process this GO :0001503 and ossification and biological process this GO :0001843 and neural tube closure and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002726 and positive regulation of T cell cytokine production and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0005164 and tumor necrosis factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005811 and lipid particle and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005938 and cell cortex and cellular component this GO :0006461 and protein complex assembly and biological process this GO :0006955 and immune response and biological process this GO :0007165 and signal transduction and biological process this GO :0007249 and I-kappaB kinase/NF-kappaB signaling and biological process this GO :0007250 and activation of NF-kappaB-inducing kinase activity and biological process this GO :0007254 and JNK cascade and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0009887 and organ morphogenesis and biological process this GO :0009898 and cytoplasmic side of plasma membrane and cellular component this GO :0010008 and endosome membrane and cellular component this GO :0016567 and protein ubiquitination and biological process this GO :0016874 and ligase activity and molecular function this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019886 and antigen processing and presentation of exogenous peptide antigen via MHC class II and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0030316 and osteoclast differentiation and biological process this GO :0031293 and membrane protein intracellular domain proteolysis and biological process this GO :0031398 and positive regulation of protein ubiquitination and biological process this GO :0031435 and mitogen-activated protein kinase kinase kinase binding and molecular function this GO :0031624 and ubiquitin conjugating enzyme binding and molecular function this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0031666 and positive regulation of lipopolysaccharide-mediated signaling pathway and biological process this GO :0031996 and thioesterase binding and molecular function this GO :0032147 and activation of protein kinase activity and biological process this GO :0032743 and positive regulation of interleukin-2 production and biological process this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0035631 and CD40 receptor complex and cellular component this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0035872 and nucleotide-binding domain, this GO :0004842: ubiquitin-protein transferase activity, this GO :0004842: ubiquitin-protein transferase activity and also this GO :0004871: signal transducer activity and also this GO :0005164: tumor necrosis factor receptor binding and also this GO :0005515: protein binding and also this GO :0008270: zinc ion binding and also this GO :0016874: ligase activity and also this GO :0019901: protein kinase binding and also this GO :0031435: mitogen-activated protein kinase kinase kinase binding and also this GO :0031624: ubiquitin conjugating enzyme binding and also this GO :0031625: ubiquitin protein ligase binding and also this GO :0031996: thioesterase binding and also this GO :0042826: histone deacetylase binding and also this GO :0043422: protein kinase B binding and also this GO :0046872: metal ion binding and also this GO :0047485: protein N-terminus binding, this GO :0004871: signal transducer activity, this GO :0005164: tumor necrosis factor receptor binding, this GO :0005515: protein binding, this GO :0008270: zinc ion binding, this GO :0016874: ligase activity, this GO :0019901: protein kinase binding, this GO :0031435: mitogen-activated protein kinase kinase kinase binding, this GO :0031624: ubiquitin conjugating enzyme binding, this GO :0031625: ubiquitin protein ligase binding, this GO :0031996: thioesterase binding, this GO :0042826: histone deacetylase binding, this GO :0043422: protein kinase B binding, this GO :0046872: metal ion binding, this GO :0047485: protein N-terminus binding, TNF receptor-associated factor 6 |
| Identity | 12036 |
| Gene | TRAF6 |
| Long gene name | TNF receptor associated factor 6 |
| Synonyms gene name | E3 ubiquitin protein ligase , TNF receptor-associated factor 6 |
| Synonyms | RNF85 |
| Locus | 11p12 |
| Discovery year | 1997-06-12 |
| Entrez gene record | 7189 |
| Pubmed identfication | 8837778 |
| RefSeq identity | NM_145803 |
| Classification | Ring finger proteins TNF receptor associated factors |
| Havana BLAST/BLAT | OTTHUMG00000166391 |
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