| Long name | FITC Conjugated, TRAF6 Polyclonal Antibody |
| Category | Conjugated Primary Antibodies |
| Conjugation | Anti-FITC Antibody |
| Host Organism | Rabbit (Oryctolagus cuniculus) |
| Target Antigen | TRAF6 |
| Specificity | This is a highly specific antibody against TRAF6 |
| Modification | Unmodified |
| Modification site | None |
| Clonality | Polyclonal |
| Clone | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen_range | 500-530/530 |
| Subcellular location | Nucleus, Cytoplasm |
| Source | KLH conjugated synthetic peptide derived from mouse TRAF6 |
| Gene ID number | 22034 |
| Swiss Prot | P70196 |
| Tested applications | IF(IHC-P) |
| Recommended dilutions | IF(IHC-P)(1:50-200) |
| Crossreactivity | Mouse, Rat, Human |
| Crossreactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background | AKT1 and AKT2, Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (By similarity), IL-1 receptor and IL-17 receptor, IRAK1, Leads to the activation of NF-kappa-B and JUN, May be essential for the formation of functional osteoclasts, Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, Represses c-Myb-mediated transactivation, Seems to also play a role in dendritic cells (DCs) maturation and/or activation, Together with MAP3K8, and thus may play a role in the regulation of immunoglobulin production, in B-lymphocytes, in response to RANK-L stimulation, mediates CD40 signals that activate ERK in B-cells and macrophages, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, together with UBE2N and UBE2V1, E3 ubiquitin ligase that |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission | 494nm/518nm |
| Synonyms | RNF85 |
| Properties | Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target | TRAF6 Conjugated |
| Short name | FITC Conjugated, TRAF6 Antibody |
| Technique | Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label | FITC |
| Alternative name | E3 ubiquitin protein ligase (Antibody to), fluorecein coupled, tumor necrosis factor receptor-associated factor 6 |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046849 and bone remodeling and biological process this GO :0046872 and metal ion binding and molecular function this GO :0047485 and protein N-terminus binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048468 and cell development and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0048661 and positive regulation of smooth muscle cell proliferation and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0050870 and positive regulation of T cell activation and biological process this GO :0051023 and regulation of immunoglobulin secretion and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051403 and stress-activated MAPK cascade and biological process this GO :0051865 and protein autoubiquitination and biological process this GO :0070423 and nucleotide-binding oli this GO merization domain containing signaling pathway and biological process this GO :0070498 and interleukin-1-mediated signaling pathway and biological process this GO :0070534 and protein K63-linked ubiquitination and biological process this GO :0070555 and response to interleukin-1 and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :2000679 and positive regulation of transcription regulatory region DNA binding and biological process, E3 ubiquitin protein ligase, MGC:3310 and RNF85, TRAF6 and IDBG-40102 and ENSG00000175104 and 7189, TRAF6 and IDBG-636763 and ENSBTAG00000036009 and 539124, Traf6 and IDBG-193222 and ENSMUSG00000027164 and 22034, leucine rich repeat containing receptor signaling pathway and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0042088 and T-helper 1 type immune response and biological process this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0042475 and odontogenesis of dentin-containing tooth and biological process this GO :0042826 and histone deacetylase binding and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043011 and myeloid dendritic cell differentiation and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043234 and protein complex and cellular component this GO :0043422 and protein kinase B binding and molecular function this GO :0043507 and positive regulation of JUN kinase activity and biological process this GO :0045084 and positive regulation of interleukin-12 biosynthetic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045410 and positive regulation of interleukin-6 biosynthetic process and biological process this GO :0045453 and bone resorption and biological process this GO :0045672 and positive regulation of osteoclast differentiation and biological process this GO :0045892 and negative regulation of transcription, nuclei, protein N-terminus binding, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000187 and activation of MAPK activity and biological process this GO :0000209 and protein polyubiquitination and biological process this GO :0001503 and ossification and biological process this GO :0001843 and neural tube closure and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002726 and positive regulation of T cell cytokine production and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0005164 and tumor necrosis factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005811 and lipid particle and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005938 and cell cortex and cellular component this GO :0006461 and protein complex assembly and biological process this GO :0006955 and immune response and biological process this GO :0007165 and signal transduction and biological process this GO :0007249 and I-kappaB kinase/NF-kappaB signaling and biological process this GO :0007250 and activation of NF-kappaB-inducing kinase activity and biological process this GO :0007254 and JNK cascade and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0009887 and organ morphogenesis and biological process this GO :0009898 and cytoplasmic side of plasma membrane and cellular component this GO :0010008 and endosome membrane and cellular component this GO :0016567 and protein ubiquitination and biological process this GO :0016874 and ligase activity and molecular function this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019886 and antigen processing and presentation of exogenous peptide antigen via MHC class II and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0030316 and osteoclast differentiation and biological process this GO :0031293 and membrane protein intracellular domain proteolysis and biological process this GO :0031398 and positive regulation of protein ubiquitination and biological process this GO :0031435 and mitogen-activated protein kinase kinase kinase binding and molecular function this GO :0031624 and ubiquitin conjugating enzyme binding and molecular function this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0031666 and positive regulation of lipopolysaccharide-mediated signaling pathway and biological process this GO :0031996 and thioesterase binding and molecular function this GO :0032147 and activation of protein kinase activity and biological process this GO :0032743 and positive regulation of interleukin-2 production and biological process this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0035631 and CD40 receptor complex and cellular component this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0035872 and nucleotide-binding domain, this GO :0004842: ubiquitin-protein transferase activity, this GO :0004842: ubiquitin-protein transferase activity and also this GO :0004871: signal transducer activity and also this GO :0005164: tumor necrosis factor receptor binding and also this GO :0005515: protein binding and also this GO :0008270: zinc ion binding and also this GO :0016874: ligase activity and also this GO :0019901: protein kinase binding and also this GO :0031435: mitogen-activated protein kinase kinase kinase binding and also this GO :0031624: ubiquitin conjugating enzyme binding and also this GO :0031625: ubiquitin protein ligase binding and also this GO :0031996: thioesterase binding and also this GO :0042826: histone deacetylase binding and also this GO :0043422: protein kinase B binding and also this GO :0046872: metal ion binding and also this GO :0047485: protein N-terminus binding, this GO :0004871: signal transducer activity, this GO :0005164: tumor necrosis factor receptor binding, this GO :0005515: protein binding, this GO :0008270: zinc ion binding, this GO :0016874: ligase activity, this GO :0019901: protein kinase binding, this GO :0031435: mitogen-activated protein kinase kinase kinase binding, this GO :0031624: ubiquitin conjugating enzyme binding, this GO :0031625: ubiquitin protein ligase binding, this GO :0031996: thioesterase binding, this GO :0042826: histone deacetylase binding, this GO :0043422: protein kinase B binding, this GO :0046872: metal ion binding, this GO :0047485: protein N-terminus binding, TNF receptor-associated factor 6 |
| Identity | 12036 |
| Gene | TRAF6 |
| Long gene name | TNF receptor associated factor 6 |
| Synonyms gene name | E3 ubiquitin protein ligase , TNF receptor-associated factor 6 |
| Locus | 11p12 |
| Discovery year | 1997-06-12 |
| Entrez gene record | 7189 |
| Pubmed identfication | 8837778 |
| RefSeq identity | NM_145803 |
| Classification | Ring finger proteins TNF receptor associated factors |
| Havana BLAST/BLAT | OTTHUMG00000166391 |
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