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Transcription activator BRG1 Antibody

Transcription activator BRG1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameTranscription activator BRG1 Antibody
Also known asTranscription activator BRG1 Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenBRG-1/SMARCA4/SNF2 beta
SpecificityThis is a highly specific antibody against BRG-1/SMARCA4/SNF2 beta
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range65-115/1647
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human of human SMARCA4/Transcription activator BRG1
Gene ID number6597
Swiss ProtP51532
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen As neural progenitors exit mitosis and differentiate into neurons, At the same time, Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex), Component of the CREST-BRG1 complex, During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state, In resting neurons, RB1 is dephosphorylated by calcineurin, The CREST-BRG1 complex also binds to the NR2B promoter, The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth, The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells, The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes, Upon calcium influx, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF), npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex, which leads to release of the repressor complex, which leads to transcriptional activation, Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ATP-dependent helicase SMARCA4, BAF190, BAF190A, BRG1-associated factor 190A, MRD16, Mitotic growth and transcription activator, Protein BRG-1, Protein brahma homolog 1, RTPS2, SMARCA4, SNF2, SNF2-beta, SNF2B, SNF2L4, SNF2LB, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4, SWI2, Transcription activator BRG1, hSNF2b, BRG1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetTranscription activator BRG1
Short nameTranscription activator BRG1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameTranscription activator BRG1 (Antibody to)
Alternative techniqueantibodies
Identity 11100
Gene SMARCA4
Long gene name SWI/SNF related, actin dependent regulator of chromatin, matrix associated, member 4 , subfamily a
Synonyms gene SNF2L4
Synonyms hSNF2b BRG1 BAF190 SNF2 SWI2 SNF2-BETA SNF2LB FLJ39786
Synonyms name SNF2-like 4 global transcription activator homologous sequence sucrose nonfermenting-like 4 mitotic growth and transcription activator BRM/SWI2-related gene 1 homeotic gene regulator nuclear protein GRB1 brahma protein-like 1 ATP-dependent helicase SMARCA4
Locus 19p13, 2
Discovery year 1995-07-17
GenBank acession D26156
Entrez gene record 6597
Pubmed identfication 8208605
RefSeq identity NM_003072
Havana BLAST/BLAT OTTHUMG00000169272
Locus Specific Databases LRG_878

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