Filters

Transferrin Receptor Antibody (CD71)

Transferrin Receptor Antibody (CD71) size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormPurified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenTransferrin Receptor (CD71)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, FACS, IHC, WB
Recommended dilutionsFlow Cytometry: 1:10-1:50, IHC (Paraffin): 1:10-1:50, Western blot: 1:1000
NotesTitration of the CD71 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis CD71 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P02786
PurityPurified
Description A second ligand, Endosomal acidification leads to iron release, It also has prognostic significance when typing tumors, On PBL, Present on T and B cell lines, The antigen is present on most dividing cells, The apotransferrin receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor, The expression of transferrin receptor is coordinately regulated with cell growth, The soluble (or serum) transferrin receptor (sTfR) is a circulating truncated form of the membrane receptor protein, The transferrin receptor is not present on resting blood lymphocytes, This antibody is an indicator of proliferation activity, Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity), Useful in studies of dividing haematopoietic and tumour cell populations, and metabolic activity, competes for binding with transferrin for an overlapping C terminal binding site, including normally cycling in vivo hematopoietic progenitor cells, it is an 85 kDa glycoprotein forming in serum a 320 kDa complex with diferric transferrin, mitogenically stimulated cells in vitro, some primary tumor cells and most proliferating cells in vitro, such as leukemias and lymphomas, the heditary hemochromatosis protein HFE, the receptor appears after activation, Cellular uptake of iron occurs via receptor mediated endocytosis of ligand occupied transferrin receptor into specialized endosomes, The most important clinical use of the sTfR determination is in the differential diagnosis between iron deficiency anaemia and the anaemia of chronic disease, The transferrin receptor has been structurally characterized as a sulfide bound dimer of identical glycoprotein subunits of 95 kDa
ImmunogenA portion of amino acids 649-677 from the human protein was used as the immunogen for this CD71 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the CD71 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetTransferrin Receptor (CD71)
Short nameTransferrin Receptor Antibody (CD71)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameTransferrin Receptor (Antibody to) (CD71)
Alternative techniqueantibodies
Identity 11763
Gene TFRC
Long gene name transferrin receptor
Synonyms gene name CD71) , transferrin receptor (p90
Synonyms CD71 TFR1 p90
Locus 3q29
Discovery year 2001-06-22
GenBank acession X01060
Entrez gene record 7037
Classification CD molecules
Havana BLAST/BLAT OTTHUMG00000155714

Similar products

Subscribe to our Newsletter