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TRF2 Antibody, ALEXA FLUOR 647

TRF2 Antibody, ALEXA FLUOR 647 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 647 Conjugated, TRF2 Polyclonal Antibody
Also known asAnti-TRF2 PAb ALEXA FLUOR 647
CategoryConjugated Primary Antibodies
Conjugated with 647, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenTRF2
SpecificityThis is a highly specific antibody against TRF2
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range350-400/542
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TRF2
Gene ID Number7014
Swiss ProtQ15554
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection, In addition to its telomeric DNA-binding role, Preferentially binds to positive supercoiled DNA, Recruits TERF2IP/RAP1 to telomeres, Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo, Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends, TERF2IP/RAP1 and DCLRE1B/Apollo, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology, Together with DCLRE1B/Apollo, Together with DCLRE1B/Apollo, including the shelterin complex, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair, required to control the amount of DNA topoisomerase (TOP1, required to recruit a number of factors and enzymes required for telomere protection, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length, without its protective activity, Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission650nm/665nm
Synonyms TRF2
Properties ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the TRF2 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 647, Alexa Fluor
Gene targetTRF2
Short nameTRF2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 647
Alternative name ALEXA FLUOR 647, TRF2 (Antibody to)
Alternative techniqueantibodies
Identity 11729
Gene TERF2
Long gene name telomeric repeat binding factor 2
Synonyms gene TRBF2
Locus 16q22, 1
Discovery year 1997-11-20
Entrez gene record 7014
Pubmed identfication 9326950 10226653
Classification Shelterin complex Myb/SANT domain containing
Havana BLAST/BLAT OTTHUMG00000137566

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