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TRF2 Antibody, Biotin Conjugated

TRF2 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, TRF2 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenTRF2
SpecificityThis is a highly specific antibody against TRF2
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range350-400/542
Subcellular locationNucleus
SourceKLH conjugated synthetic peptide derived from human TRF2
Gene ID number7014
Swiss ProtQ15554
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection, In addition to its telomeric DNA-binding role, Preferentially binds to positive supercoiled DNA, Recruits TERF2IP/RAP1 to telomeres, Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo, Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends, TERF2IP/RAP1 and DCLRE1B/Apollo, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology, Together with DCLRE1B/Apollo, Together with DCLRE1B/Apollo, including the shelterin complex, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair, required to control the amount of DNA topoisomerase (TOP1, required to recruit a number of factors and enzymes required for telomere protection, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length, without its protective activity, Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms TRF2
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetTRF2 Conjugated
Short name Conjugated, TRF2 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, TRF2 (Antibody to)
Alternative techniqueantibodies
Identity 11729
Gene TERF2
Long gene name telomeric repeat binding factor 2
Synonyms gene TRBF2
Locus 16q22, 1
Discovery year 1997-11-20
Entrez gene record 7014
Pubmed identfication 9326950 10226653
Classification Shelterin complex Myb/SANT domain containing
Havana BLAST/BLAT OTTHUMG00000137566

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