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TRIM21 Antibody, ALEXA FLUOR 350

TRIM21 Antibody, ALEXA FLUOR 350 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 350 Conjugated, TRIM21 Polyclonal Antibody
Also known asAnti-TRIM21 PAb ALEXA FLUOR 350
CategoryConjugated Primary Antibodies
Conjugated with 350, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenTRIM21
SpecificityThis is a highly specific antibody against TRIM21
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range100-150/475
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TRIM21
Gene ID Number6737
Swiss ProtP19474
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
CrossreactivityHuman
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), At least two isoforms are present in nucleated and red blood cells, Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes, Enhances the decapping activity of DCP2, Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules, Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination, Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling, Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3, Plays a role in the regulation of the cell cycle progression, Promotes IRF8 ubiquitination, The common feature of these proteins is their ability to bind HY RNAs, UBE2D1, UBE2D2, UBE2E1 and UBE2E2, and tissue specific differences in RO/SSA proteins have been identified, thereby promoting its degradation by the proteasome, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway, 2, E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission343nm/442nm
Synonyms RNF81 RO52 Ro/SSA
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 350, Alexa Fluor
Gene targetTRIM21
Short nameTRIM21 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 350
Alternative name ALEXA FLUOR 350, TRIM21 (Antibody to)
Alternative techniqueantibodies
Identity 11312
Gene TRIM21
Long gene name tripartite motif containing 21
Synonyms gene SSA1
Synonyms gene name Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro) tripartite motif-containing 21
Locus 11p15, 3 , 5-p15
Discovery year 1994-01-06
GenBank acession AF391283
Entrez gene record 6737
Pubmed identfication 8094596
RefSeq identity NM_003141
Classification Tripartite motif containing Ring finger proteins
Havana BLAST/BLAT OTTHUMG00000165701

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