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TRIM21 Antibody, Biotin Conjugated

TRIM21 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, TRIM21 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenTRIM21
SpecificityThis is a highly specific antibody against TRIM21
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range100-150/475
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from human TRIM21
Gene ID number6737
Swiss ProtP19474
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
CrossreactivityHuman
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), At least two isoforms are present in nucleated and red blood cells, Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes, Enhances the decapping activity of DCP2, Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules, Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination, Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling, Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3, Plays a role in the regulation of the cell cycle progression, Promotes IRF8 ubiquitination, The common feature of these proteins is their ability to bind HY RNAs, UBE2D1, UBE2D2, UBE2E1 and UBE2E2, and tissue specific differences in RO/SSA proteins have been identified, thereby promoting its degradation by the proteasome, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway, 2, E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms RNF81 RO52 Ro/SSA
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetTRIM21 Conjugated
Short name Conjugated, TRIM21 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, TRIM21 (Antibody to)
Alternative techniqueantibodies
Identity 11312
Gene TRIM21
Long gene name tripartite motif containing 21
Synonyms gene SSA1
Synonyms gene name Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro) tripartite motif-containing 21
Locus 11p15, 3 , 5-p15
Discovery year 1994-01-06
GenBank acession AF391283
Entrez gene record 6737
Pubmed identfication 8094596
RefSeq identity NM_003141
Classification Tripartite motif containing Ring finger proteins
Havana BLAST/BLAT OTTHUMG00000165701

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