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TrkA Antibody, ALEXA FLUOR 555

TrkA Antibody, ALEXA FLUOR 555 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 555 Conjugated, TrkA Polyclonal Antibody
Also known asAnti-TrkA PAb ALEXA FLUOR 555
CategoryConjugated Primary Antibodies
Conjugated with 555, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenTrkA
SpecificityThis is a highly specific antibody against TrkA
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range740-796/796
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Trk A
Gene ID Number4914
Swiss ProtP04629
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation, FRS2, High affinity receptor for NGF which is its primary ligand, However, In absence of ligand and activation, Isoform TrkA-III is resistant to NGF, Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival, Recruits, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation, Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival, Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival, Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival, Upon dimeric NGF ligand-binding, autophosphorylation and activation, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade, differentiation and survival of sympathetic and nervous neurons, it can also bind and be activated by NTF3/neurotrophin-3, making the survival of neurons dependent on trophic factors, may promote cell death, phosphorylates and/or activates several downstream effectors including SHC1, undergoes homodimerization, Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission553nm/568nm
Synonyms TRK TRKA MTC
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 555, Alexa Fluor
Gene targetTrkA
Short nameTrkA Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 555
Alternative name ALEXA FLUOR 555, TrkA (Antibody to)
Alternative techniqueantibodies
Identity 8031
Gene NTRK1
Long gene name neurotrophic receptor tyrosine kinase 1
Synonyms gene name neurotrophic tyrosine kinase, receptor, type 1
Synonyms name high affinity nerve growth factor receptor
Locus 1q23, 1
Discovery year 1991-07-18
GenBank acession Y09028
Entrez gene record 4914
Pubmed identfication 2869410
RefSeq identity NM_002529
Classification Immunoglobulin like domain containing Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000041304
Locus Specific Databases Inherited Peripheral Neuropathies Mutation Database LRG_261

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