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TrkA Antibody (NTRK1)
TrkA Antibody (NTRK1) size: 0.08 ml 199
Supplier
NJS POLY
Price
199
Size
0.08 ml
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| Category | Antibody |
| Concentration | pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form | Antigen affinity purified |
| Conjugation | Unconjugated |
| Clone | Polyclonal antibody |
| Recognised antigen | TrkA (NTRK1) |
| Host animal | Rabbit (Oryctolagus cuniculus) |
| Clonality | Polyclonal (rabbit origin) |
| Species reactivity | Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications | ELISA, FACS, WB |
| Recommended dilutions | Flow Cytometry: 1:10-1:50, Western blot: 1:1000 |
| Notes | Titration of the TrkA antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use | This TrkA antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot # | P04629 |
| Purity | Antigen affinity |
| Description | Alternate transcriptional splice variants of this gene have been found, Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation, Isoform 3 is resistant to NGF, Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed, Its presence leads to cell differentiation and may play a role in specifying sensory neuron subtypes, This kinase is a membrane-bound receptor that, [Isoform 3 information courtesy of UniProt], but only three have been characterized to date, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade, phosphorylates itself and members of the MAPK pathway, upon neurotrophin binding, This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family |
| Immunogen | A portion of amino acids 654-683 from the human protein was used as the immunogen for this TrkA antibody |
| Storage | Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot the TrkA antibody and store frozen at -20 deg, Store at 4oC for up to one month |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target | TrkA (NTRK1) |
| Short name | TrkA Antibody (NTRK1) |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | classification 1), receptor, TrkA (Antibody to) (neurotrophic tyrosine kinase |
| Alternative technique | antibodies |
| Alternative to gene target | BT, Cell surfaces, MTC and p140-TrkA and TRK and Trk-A and TRK1 and TRKA, NTRK1 and IDBG-103632 and ENSG00000198400 and 4914, Ntrk1 and IDBG-158646 and ENSMUSG00000028072 and 18211, glutamatergic and biological process this GO :0060009 and Sertoli cell development and biological process this GO :0060385 and axonogenesis involved in innervation and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0071316 and cellular response to nicotine and biological process this GO :0071363 and cellular response to growth factor stimulus and biological process this GO :1901215 and negative regulation of neuron death and biological process this GO :1990090 and cellular response to nerve growth factor stimulus and biological process, receptor, this GO :0000186 and activation of MAPKK activity and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0005030 and neurotrophin receptor activity and molecular function this GO :0005166 and neurotrophin p75 receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005768 and endosome and cellular component this GO :0005769 and early endosome and cellular component this GO :0005770 and late endosome and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007190 and activation of adenylate cyclase activity and biological process this GO :0007202 and activation of phospholipase C activity and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007265 and Ras protein signal transduction and biological process this GO :0007399 and nervous system development and biological process this GO :0007411 and axon guidance and biological process this GO :0007568 and aging and biological process this GO :0007611 and learning or memory and biological process this GO :0007623 and circadian rhythm and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009314 and response to radiation and biological process this GO :0009986 and cell surface and cellular component this GO :0010465 and nerve growth factor receptor activity and molecular function this GO :0010623 and developmental programmed cell death and biological process this GO :0010976 and positive regulation of neuron projection development and biological process this GO :0014823 and response to activity and biological process this GO :0016772 and transferase activity, this GO :0004672: protein kinase activity, this GO :0004672: protein kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0004714: transmembrane receptor protein tyrosine kinase activity and also this GO :0005030: neurotrophin receptor activity and also this GO :0005166: neurotrophin p75 receptor binding and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0010465: nerve growth factor receptor activity and also this GO :0016772: transferase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0004714: transmembrane receptor protein tyrosine kinase activity, this GO :0005030: neurotrophin receptor activity, this GO :0005166: neurotrophin p75 receptor binding, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0010465: nerve growth factor receptor activity, this GO :0016772: transferase activity, this GO :0042803: protein homodimerization activity, this GO :0043121: neurotrophin binding, this GO :0046875: ephrin receptor binding, this GO :0048406: nerve growth factor binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0042803: protein homodimerization activity and also this GO :0043121: neurotrophin binding and also this GO :0046875: ephrin receptor binding and also this GO :0048406: nerve growth factor binding, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019233 and sensory perception of pain and biological process this GO :0021553 and olfactory nerve development and biological process this GO :0030183 and B cell differentiation and biological process this GO :0030424 and axon and cellular component this GO :0030425 and dendrite and cellular component this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0031667 and response to nutrient levels and biological process this GO :0031901 and early endosome membrane and cellular component this GO :0031902 and late endosome membrane and cellular component this GO :0032320 and positive regulation of Ras GTPase activity and biological process this GO :0035094 and response to nicotine and biological process this GO :0038179 and neurotrophin signaling pathway and biological process this GO :0038180 and nerve growth factor signaling pathway and biological process this GO :0042490 and mechanoreceptor differentiation and biological process this GO :0042493 and response to drug and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043025 and neuronal cell body and cellular component this GO :0043068 and positive regulation of programmed cell death and biological process this GO :0043121 and neurotrophin binding and molecular function this GO :0043234 and protein complex and cellular component this GO :0043235 and receptor complex and cellular component this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0045471 and response to ethanol and biological process this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0046579 and positive regulation of Ras protein signal transduction and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0046875 and ephrin receptor binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0048406 and nerve growth factor binding and molecular function this GO :0048485 and sympathetic nervous system development and biological process this GO :0048678 and response to axon injury and biological process this GO :0050965 and detection of temperature stimulus involved in sensory perception of pain and biological process this GO :0050966 and detection of mechanical stimulus involved in sensory perception of pain and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051599 and response to hydrostatic pressure and biological process this GO :0051602 and response to electrical stimulus and biological process this GO :0051968 and positive regulation of synaptic transmission, type 1, 22873 and IDBG-631386 and ENSBTAG00000003060 and 353111, neurotrophic tyrosine kinase |
| Identity | 8031 |
| Gene | NTRK1 |
| Long gene name | neurotrophic receptor tyrosine kinase 1 |
| Synonyms gene name | neurotrophic tyrosine kinase, receptor, type 1 |
| Synonyms | TRK TRKA MTC |
| Synonyms name | high affinity nerve growth factor receptor |
| Locus | 1q23, 1 |
| Discovery year | 1991-07-18 |
| GenBank acession | Y09028 |
| Entrez gene record | 4914 |
| Pubmed identfication | 2869410 |
| RefSeq identity | NM_002529 |
| Classification | Immunoglobulin like domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT | OTTHUMG00000041304 |
| Locus Specific Databases | Inherited Peripheral Neuropathies Mutation Database LRG_261 |