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TrkB Antibody, ALEXA FLUOR 594

TrkB Antibody, ALEXA FLUOR 594 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 594 Conjugated, TrkB Polyclonal Antibody
Also known asAnti-TrkB PAb ALEXA FLUOR 594
CategoryConjugated Primary Antibodies
Conjugated with 594, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenTrkB
SpecificityThis is a highly specific antibody against TrkB
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range370-429/822
Subcellular locationExtracellular
SourceKLH conjugated synthetic peptide derived from rat TrkB
Gene ID Number4915
Swiss ProtQ16620
Tested applications IF(IHC-P), FCM
Recommended dilutions IF(IHC-P)(1:50-200), FCM(1:20-100)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2, FRS2, FRS2, Hence, May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia, PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival, Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4, Recruits, SH2B1, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades, Thereby, Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity, Through SHC1, Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival, Upon ligand-binding, and synapse formation and plasticity, autophosphorylation and activation, differentiation, it is able to suppress anoikis, migration, phosphorylates and/or activates several downstream effectors including SHC1, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation, proliferation, the apoptosis resulting from loss of cell-matrix interactions, undergoes homodimerization, Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission590nm/617nm
Synonyms TRKB
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation 594, ALEXA FLUOR®, Alexa Fluor
ConjugatedAlexa conjugate 1
Gene targetTrkB
Short nameTrkB Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 594
Alternative name ALEXA FLUOR 594, TrkB (Antibody to)
Alternative techniqueantibodies
Identity 8032
Gene NTRK2
Long gene name neurotrophic receptor tyrosine kinase 2
Synonyms gene name neurotrophic tyrosine kinase, receptor, type 2
Locus 9q21, 33
Discovery year 1991-07-18
GenBank acession AF410902
Entrez gene record 4915
Pubmed identfication 7789988
Classification I-set domain containing Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000020120

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