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TRPV1/VR1 Antibody

TRPV1/VR1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameTRPV1/VR1 Primary Polyclonal Antibody
Also known asTRPV1/VR1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenTRPV1/VR1
SpecificityThis is a highly specific antibody against TRPV1/VR1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range800-839/839
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human VR1
Gene ID number7442
Swiss ProtQ8NER1
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Activation by vanilloids, Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects, Can be activated by endogenous compounds, Involved in mediation of inflammatory pain and hyperalgesia, Mild extracellular acidic pH (6, Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons, Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity), and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state, including 12-hydroperoxytetraenoic acid and bradykinin, like capsaicin, whereas acidic conditions (pH <, which involves PKC isozymes and PCL, 5) potentiates channel activation by noxious heat and vanilloids, 6) directly activate the channel, Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Capsaicin receptor, OTRPC1, Osm-9-like TRP channel 1, Transient receptor potential cation channel subfamily V member 1, TrpV1, Vanilloid receptor 1, VR1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetTRPV1/VR1
Short nameTRPV1/VR1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameTRPV1/VR1 (Antibody to)
Alternative techniqueantibodies
Identity 12716
Gene TRPV1
Long gene name transient receptor potential cation channel subfamily V member 1
Synonyms gene VR1
Synonyms gene name member 1 , subfamily V, vanilloid receptor subtype 1 transient receptor potential cation channel
Locus 17p13, 2
Discovery year 1997-12-05
GenBank acession AJ272063
Entrez gene record 7442
Pubmed identfication 9349813 11549313 16382100
RefSeq identity NM_018727
Classification Ankyrin repeat domain containing Transient receptor potential cation channels
Havana BLAST/BLAT OTTHUMG00000177649

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