| Long name | TSC2(Ser1798) Primary Polyclonal Antibody |
| Also known as | TSC2(Ser1798) PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | TSC2 Ser1798 |
| Specificity | Phosphorylation site corresponds to Ser1805 in mouse and Ser1800 in rat, This is a highly specific antibody against TSC2 Ser1798 |
| Modification(s) | Phosphorylation |
| Modification site(s) | Ser1798 |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 1793-1800/1807 |
| Subcellular location | Cell membrane, Cytoplasm |
| Source | KLH conjugated synthetic phosphopeptide derived from human Tuberin around the phosphorylation site of Ser1798 |
| Gene ID number | 7249 |
| Swiss Prot | P49815 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, Implicated as a tumor suppressor, Involved in microtubule-mediated protein transport, Mutations in TSC2 lead to constitutive activation of RAP1A in tumors, Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro, a direct activator of the protein kinase activity of mTORC1, but this seems to be due to unregulated mTOR signaling, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling, In complex with TSC1 |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | PPP1R160, TSC2, TSC4, Tuberin, Tuberous sclerosis 2 protein, LAM |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | TSC2(Ser1798) |
| Short name | TSC2(Ser1798) Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | tuberous sclerosis 2(Ser1798) (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | 14-3-3 protein binding, LAM and PPP1R160 and TSC4, TSC2 and IDBG-635000 and ENSBTAG00000020617 and 504985, TSC2 and IDBG-9819 and ENSG00000103197 and 7249, Tsc2 and IDBG-147651 and ENSMUSG00000002496 and 22084, nuclei, this GO :0001666 and response to hypoxia and biological process this GO :0001843 and neural tube closure and biological process this GO :0005096 and GTPase activator activity and molecular function this GO :0005488 and binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005901 and caveola and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0006606 and protein import into nucleus and biological process this GO :0006897 and endocytosis and biological process this GO :0006953 and acute-phase response and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007165 and signal transduction and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007507 and heart development and biological process this GO :0008104 and protein localization and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0014065 and phosphatidylinositol 3-kinase signaling and biological process this GO :0014067 and negative regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0016020 and membrane and cellular component this GO :0016192 and vesicle-mediated transport and biological process this GO :0019902 and phosphatase binding and molecular function this GO :0030030 and cell projection organization and biological process this GO :0030100 and regulation of endocytosis and biological process this GO :0030178 and negative regulation of Wnt signaling pathway and biological process this GO :0030425 and dendrite and cellular component this GO :0030426 and growth cone and cellular component this GO :0032007 and negative regulation of TOR signaling and biological process this GO :0032320 and positive regulation of Ras GTPase activity and biological process this GO :0033596 and TSC1-TSC2 complex and cellular component this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043005 and neuron projection and cellular component this GO :0043025 and neuronal cell body and cellular component this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043234 and protein complex and cellular component this GO :0043407 and negative regulation of MAP kinase activity and biological process this GO :0043491 and protein kinase B signaling and biological process this GO :0043547 and positive regulation of GTPase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045184 and establishment of protein localization and biological process this GO :0045792 and negative regulation of cell size and biological process this GO :0046626 and regulation of insulin receptor signaling pathway and biological process this GO :0046627 and negative regulation of insulin receptor signaling pathway and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048009 and insulin-like growth factor receptor signaling pathway and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0050680 and negative regulation of epithelial cell proliferation and biological process this GO :0050918 and positive chemotaxis and biological process this GO :0051056 and regulation of small GTPase mediated signal transduction and biological process this GO :0051260 and protein homooli this GO merization and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051726 and regulation of cell cycle and biological process this GO :0051898 and negative regulation of protein kinase B signaling and biological process this GO :0071889 and 14-3-3 protein binding and molecular function, this GO :0005096: GTPase activator activity, this GO :0005096: GTPase activator activity and also this GO :0005488: binding and also this GO :0005515: protein binding and also this GO :0019902: phosphatase binding and also this GO :0042803: protein homodimerization activity and also this GO :0046982: protein heterodimerization activity and also this GO :0071889: 14-3-3 protein binding, this GO :0005488: binding, this GO :0005515: protein binding, this GO :0019902: phosphatase binding, this GO :0042803: protein homodimerization activity, this GO :0046982: protein heterodimerization activity, this GO :0071889: 14-3-3 protein binding, tuberous sclerosis 2 |
| Identity | 12363 |
| Gene | TSC2 |
| Long gene name | tuberous sclerosis 2 |
| Synonyms gene | TSC4 |
| Synonyms | tuberin LAM PPP1R160 |
| Synonyms name | protein phosphatase 1, regulatory subunit 160 |
| Locus | 16p13, 3 |
| Discovery year | 1989-05-25 |
| GenBank acession | AB014460 |
| Entrez gene record | 7249 |
| Pubmed identfication | 1303246 7558029 |
| RefSeq identity | NM_000548 |
| Classification | Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT | OTTHUMG00000128745 |
| Locus Specific Databases | TSC2 Mutation Database Tuberous sclerosis database LRG_487 |
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