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Tuberin Antibody

Tuberin Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameTuberin Primary Polyclonal Antibody
Also known asTuberin PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenTuberin
SpecificityThis is a highly specific antibody against Tuberin
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range1600-1650/1809
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Tuberin
Gene ID number7249
Swiss ProtP49815
Tested Applications IF(IHC-P), IHC-P
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, Implicated as a tumor suppressor, Involved in microtubule-mediated protein transport, Mutations in TSC2 lead to constitutive activation of RAP1A in tumors, Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro, a direct activator of the protein kinase activity of mTORC1, but this seems to be due to unregulated mTOR signaling, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling, In complex with TSC1
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names PPP1R160, TSC2, TSC4, Tuberin, Tuberous sclerosis 2 protein, LAM
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetTuberin
Short nameTuberin Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameTuberin (Antibody to)
Alternative techniqueantibodies
Identity 12365
Gene TSC4
Long gene name tuberous sclerosis 2
Synonyms tuberin LAM PPP1R160 TSC2
Synonyms name protein phosphatase 1, regulatory subunit 160
Locus 16p13, 3
Discovery year 1989-05-25
GenBank acession AB014460
Entrez gene record 7249
Pubmed identfication 1303246 7558029
RefSeq identity NM_000548
Classification Protein phosphatase 1 regulatory subunits
Havana BLAST/BLAT OTTHUMG00000128745
Locus Specific Databases TSC2 Mutation Database Tuberous sclerosis database LRG_487

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