Filters

Twinkle/ATXN8 Antibody

Twinkle/ATXN8 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameTwinkle/ATXN8 Primary Polyclonal Antibody
Also known asTwinkle/ATXN8 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenTwinkle/ATXN8
SpecificityThis is a highly specific antibody against Twinkle/ATXN8
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Twinkle/ATXN8
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Colocalized with mtDNA (mitochondrial DNA) in mitochondrial nucleoids, Defects in the gene encoding Twinkle are the cause of two conditions: progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant 3 (PEOA3) and sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), PEOA3, PEOA3 is characterized by ptosis and weak muscles, SANDO or TWINL, Twinkle is expressed at high levels in testis, Twinkle is important in the metabolism and maintenance of mtDNA, also known as PEO1 (Progressive external ophthalmoplegia 1 protein), dysarthria and sensory ataxic neuropathies, is a mitochondrial protein that functions as a 5â, nucleotide-dependent DNA helicase, pancreas and skeletal muscle and exists as three isoforms due to alternative splicing events, playing a crucial role in the regulation of mtDNA copy numbers, while SANDO is characterized by ophthalmoparesis, &euro, &euro, &trade, &trade, -3â, Twinkle
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names mitochondrial, ATXN 8, ATXN8, Ataxin 8, Ataxin8, C10 orf2, C10orf 2, C10orf2, Chromosome 10 open reading frame 2, IOSCA, PEO, PEO 1, PEO1, PEOA3, Progressive external ophthalmoplegia 1 protein, SANDO, SCA 8, SCA8, T7 gp4 like protein with intramitochondrial nucleoid localization, T7 like mitochondrial DNA helicase, TWINL, Twinkle protein
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetTwinkle/ATXN8
Short nameTwinkle/ATXN8 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameTwinkle/ATXN8 (Antibody to)
Alternative techniqueantibodies
Identity 32925
Gene ATXN8
Long gene name ataxin 8
Locus 13q21, 33
Discovery year 2006-07-18
GenBank acession DQ641254
Entrez gene record 724066
Pubmed identfication 16804541
Classification Ataxins

Similar products

Subscribe to our Newsletter