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Tyrosine Kinase Receptor Antibody, Cy3 Conjugated

Tyrosine Kinase Receptor Antibody, Cy3 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy3 Conjugated, Tyrosine Kinase Receptor Antibody
CategoryConjugated Primary Antibodies
Conjugationcy3 conjugation kit
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenTrk A + B + C
SpecificityThis is a highly specific antibody against Trk A + B + C
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range640-676/796
Subcellular locationCytoplasm
SourceKLH conjugated synthetic peptide derived from human Trk A
Gene ID number4914
Swiss ProtP04629
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation, FRS2, High affinity receptor for NGF which is its primary ligand, However, In absence of ligand and activation, Isoform TrkA-III is resistant to NGF, Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival, Recruits, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation, Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival, Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival, Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival, Upon dimeric NGF ligand-binding, autophosphorylation and activation, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade, differentiation and survival of sympathetic and nervous neurons, it can also bind and be activated by NTF3/neurotrophin-3, making the survival of neurons dependent on trophic factors, may promote cell death, phosphorylates and/or activates several downstream effectors including SHC1, undergoes homodimerization, Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission512, 550nm/570, 615nm
Synonyms High affinity nerve growth factor receptor, NTRK1, Neurotrophic tyrosine kinase receptor type 1, TRK, TRK1, TRK1-transforming tyrosine kinase protein, TRKA, Trk-A, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, gp14trk, p14-TrkA, MTC
Properties 1 of the Tyrosine Kinase Receptor Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetTyrosine Kinase Receptor Conjugated
Short name Conjugated, Tyrosine Kinase Receptor Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy3
Alternative name cyanine 3 coupled, Tyrosine phosphorylation catalyst Receptor (Antibody to)
Alternative techniqueantibodies

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