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UBE3A/E6-AP Antibody, Cy3 Conjugated

UBE3A/E6-AP Antibody, Cy3 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy3 Conjugated, UBE3A/E6-AP Polyclonal Antibody
CategoryConjugated Primary Antibodies
Conjugationcy3 conjugation kit
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenUBE3A/E6-AP
SpecificityThis is a highly specific antibody against UBE3A/E6-AP
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from human UBE3A/E6-AP
Gene ID number7337
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Genetic mutations that impair E6-AP activity result in the accumulation of p53 in the cytoplasm, HHR23A, Previous studies have indicated that E6-AP associates with the human papillomavirus E6 oncogene, Several substrates of E6-AP have been identified and include the tumor suppressor protein p53 and the mammalian homolog of Rad23, This conjugation is facilitated by the enzymatic activity of E3 ubiquitin ligase family members such as E6-AP, Ubiquitin (Ub) is directly conjugated to protein substrates by the transfer of Ub from an E2 ubiquitin conjugating enzyme to the target protein, and, in many instances, these mutations are associated with the development of the rare neurodevelopmental disorder Angelman syndrome (AS), which complexes with p53 and thereby potentiates E6-AP mediated ubiquitination of p53, which is characterized by severe motor dysfunction and mental retardation, which selectively targets proteins for degradation by the 26S proteasome, E6-associating protein is a component of the ubiquitin-mediated proteolytic pathway
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission512, 550nm/570, 615nm
Synonyms AS ANCR E6-AP FLJ26981
Properties 1 of the UBE3A/E6-AP Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetUBE3A/E6-AP Conjugated
Short name Conjugated, UBE3A/E6-AP Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelAP
Alternative name cyanine 3 coupled, ubiquitin protein ligase E3A/E6-AP (Antibody to)
Alternative techniqueantibodies
Alternative to gene target ANCR and AS and E6-AP and EPVE6AP and HPVE6A, UBE3A and IDBG-4274 and ENSG00000114062 and 7337, UBE3A and IDBG-628537 and ENSBTAG00000002487 and 100335247, Ube3a and IDBG-190437 and ENSMUSG00000025326 and 22215, ligase activity, nuclei, this GO :0000502 and proteasome complex and cellular component this GO :0001541 and ovarian follicle development and biological process this GO :0003713 and transcription coactivator activity and molecular function this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006508 and proteolysis and biological process this GO :0006511 and ubiquitin-dependent protein catabolic process and biological process this GO :0007420 and brain development and biological process this GO :0014068 and positive regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0016032 and viral process and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0016874 and ligase activity and molecular function this GO :0030521 and androgen receptor signaling pathway and biological process this GO :0035037 and sperm entry and biological process this GO :0042787 and protein ubiquitination involved in ubiquitin-dependent protein catabolic process and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0051865 and protein autoubiquitination and biological process this GO :0060736 and prostate gland growth and biological process this GO :0070936 and protein K48-linked ubiquitination and biological process, this GO :0003713: transcription coactivator activity, this GO :0003713: transcription coactivator activity and also this GO :0004842: ubiquitin-protein transferase activity and also this GO :0005515: protein binding and also this GO :0016874: ligase activity, this GO :0004842: ubiquitin-protein transferase activity, this GO :0005515: protein binding, this GO :0016874: ligase activity, 533136, ubiquitin protein ligase E3A
Identity 12496
Gene UBE3A
Long gene name ubiquitin protein ligase E3A
Synonyms gene EPVE6AP HPVE6A
Synonyms gene name human papilloma virus E6-associated protein
Synonyms name Angelman syndrome
Locus 15q11, 2
Discovery year 1993-10-21
GenBank acession AF002224
Entrez gene record 7337
Pubmed identfication 8221889
RefSeq identity NM_000462
Havana BLAST/BLAT OTTHUMG00000171548
Locus Specific Databases Manchester LOVD LRG_15 , NGRL

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