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UNC5B/UNC5H2 Antibody, Cy7 Conjugated

UNC5B/UNC5H2 Antibody, Cy7 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, UNC5B/UNC5H2 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenUNC5B/UNC5H2
SpecificityThis is a highly specific antibody against UNC5B/UNC5H2
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Subcellular locationExtracellular
SourceKLH conjugated synthetic peptide derived from human UNC5B
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Additionally, Hence, In fact, The expression of UNC5H receptors is down-regulated in multiple cancers, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, UNC5H receptors express widely in cells that migrate, UNC5H receptors induce apoptosis when cleaved by a caspase, UNC5H2, also designated unc-5 homolog B or p53-regulated receptor for death and life protein 1 (p53RDL1) is highly expressed in brain with lower levels of expression observed in developing lung, and kidney cancers, breast, but mutation of these receptors provides a potential mechanism for tumorigenicity, but this activity is blocked by the binding of netrin-1, cartilage, in the absence of netrin-1, including colorectal, kidney and hematopoietic and immune tissues, lung, ovary, producing an intracellular fragment containing a death domain, stomach, uterus, where they bind the G protein G Alpha 1-2 to inhibit G protein signaling, The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms UNC5H2 p53RDL1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetUNC5B/UNC5H2 Conjugated
Short name Conjugated, UNC5B/UNC5H2 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, elegans)/UNC5H2 (Antibody to), unc-5 homolog B (C
Alternative techniqueantibodies
Alternative to gene target Plasma membranes, UNC5B and IDBG-629823 and ENSBTAG00000014270 and 100851524, UNC5B and IDBG-77562 and ENSG00000107731 and 219699, Unc5b and IDBG-154989 and ENSMUSG00000020099 and 107449, elegans), protein binding, this GO :0005515 and protein binding and molecular function this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0014068 and positive regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0033564 and anterior/posterior axon guidance and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :2001240 and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, this GO :0005515: protein binding, this GO :0005515: protein binding, 524942, unc-5 homolog B (C
Identity 12568
Gene UNC5B
Long gene name unc-5 netrin receptor B
Synonyms gene name elegans) , unc5 (C, elegans homolog) b unc-5 homolog B (C
Locus 10q22, 1
Discovery year 1998-12-09
GenBank acession AB096256
Entrez gene record 219699
Pubmed identfication 12655055 20693423
RefSeq identity NM_170744
Classification I-set domain containing
Havana BLAST/BLAT OTTHUMG00000018422

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