| Long name | VAV3 Primary Polyclonal Antibody |
| Also known as | VAV3 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | VAV3 |
| Specificity | This is a highly specific antibody against VAV3 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 710-760/847 |
| Subcellular location | Cytoplasm |
| Source | KLH conjugated synthetic peptide derived from mouse VAV3 |
| Gene ID number | 57257 |
| Swiss Prot | Q9R0C8 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Binds physically to the nucleotide-free states of those GTPases (By similarity), Does not affect integrin beta-1-mediated adhesion, In osteoclasts, In the course of wound healing, Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly, May be important for integrin-mediated signaling, Necessary for proper wound healing, Plays an important role in angiogenesis, Rac1, Responsible for integrin beta-2-mediated macrophage adhesion and, RhoG and, This signaling pathway involves RAC1, a crucial event for osteoclast proper cytoskeleton organization and function, activation, along with SYK tyrosine kinase, at least in some cell types, but not RHO, contributes to beta-3-mediated adhesion, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils, to a lesser extent, to a lesser extent, Exchange factor for GTP-binding proteins RhoA |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | A530094I06Rik, AA986410, Guanine nucleotide exchange factor VAV3, VAV-3, Vav3, 1, Idd18 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | VAV3 |
| Short name | VAV3 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | vav 3 guanine nucleotide exchange factor (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | Plasma membranes, VAV3 and IDBG-100649 and ENSG00000134215 and 10451, VAV3 and IDBG-635847 and ENSBTAG00000031575 and 521961, Vav3 and IDBG-188386 and ENSMUSG00000033721 and 57257, metal ion binding, this GO :0001525 and angiogenesis and biological process this GO :0005070 and SH3/SH2 adaptor activity and molecular function this GO :0005085 and guanyl-nucleotide exchange factor activity and molecular function this GO :0005089 and Rho guanyl-nucleotide exchange factor activity and molecular function this GO :0005096 and GTPase activator activity and molecular function this GO :0005154 and epidermal growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006906 and vesicle fusion and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007596 and blood coagulation and biological process this GO :0009967 and positive regulation of signal transduction and biological process this GO :0016477 and cell migration and biological process this GO :0030031 and cell projection assembly and biological process this GO :0030032 and lamellipodium assembly and biological process this GO :0030168 and platelet activation and biological process this GO :0030593 and neutrophil chemotaxis and biological process this GO :0030676 and Rac guanyl-nucleotide exchange factor activity and molecular function this GO :0030890 and positive regulation of B cell proliferation and biological process this GO :0032314 and regulation of Rac GTPase activity and biological process this GO :0032319 and regulation of Rho GTPase activity and biological process this GO :0032321 and positive regulation of Rho GTPase activity and biological process this GO :0035023 and regulation of Rho protein signal transduction and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038096 and Fc-gamma receptor signaling pathway involved in pha this GO cytosis and biological process this GO :0042493 and response to drug and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043087 and regulation of GTPase activity and biological process this GO :0043547 and positive regulation of GTPase activity and biological process this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0045785 and positive regulation of cell adhesion and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0050853 and B cell receptor signaling pathway and biological process this GO :0051056 and regulation of small GTPase mediated signal transduction and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0097190 and apoptotic signaling pathway and biological process, this GO :0005070: SH3/SH2 adaptor activity, this GO :0005070: SH3/SH2 adaptor activity and also this GO :0005085: guanyl-nucleotide exchange factor activity and also this GO :0005089: Rho guanyl-nucleotide exchange factor activity and also this GO :0005096: GTPase activator activity and also this GO :0005154: epidermal growth factor receptor binding and also this GO :0005515: protein binding and also this GO :0030676: Rac guanyl-nucleotide exchange factor activity and also this GO :0046872: metal ion binding, this GO :0005085: guanyl-nucleotide exchange factor activity, this GO :0005089: Rho guanyl-nucleotide exchange factor activity, this GO :0005096: GTPase activator activity, this GO :0005154: epidermal growth factor receptor binding, this GO :0005515: protein binding, this GO :0030676: Rac guanyl-nucleotide exchange factor activity, this GO :0046872: metal ion binding, vav 3 guanine nucleotide exchange factor |
| Identity | 12659 |
| Gene | VAV3 |
| Long gene name | vav guanine nucleotide exchange factor 3 |
| Synonyms gene name | vav 3 oncogene vav 3 guanine nucleotide exchange factor |
| Locus | 1p13, 3 |
| Discovery year | 1999-07-07 |
| GenBank acession | AF118886 |
| Entrez gene record | 10451 |
| RefSeq identity | NM_006113 |
| Classification | Rho guanine nucleotide exchange factors Pleckstrin homology domain containing SH2 domain containing |
| Havana BLAST/BLAT | OTTHUMG00000010995 |
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