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VAV3 Antibody, Biotin Conjugated

VAV3 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, VAV3 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenVAV3
SpecificityThis is a highly specific antibody against VAV3
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range710-760/847
Subcellular locationCytoplasm
SourceKLH conjugated synthetic peptide derived from mouse VAV3
Gene ID number57257
Swiss ProtQ9R0C8
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Binds physically to the nucleotide-free states of those GTPases (By similarity), Does not affect integrin beta-1-mediated adhesion, In osteoclasts, In the course of wound healing, Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly, May be important for integrin-mediated signaling, Necessary for proper wound healing, Plays an important role in angiogenesis, Rac1, Responsible for integrin beta-2-mediated macrophage adhesion and, RhoG and, This signaling pathway involves RAC1, a crucial event for osteoclast proper cytoskeleton organization and function, activation, along with SYK tyrosine kinase, at least in some cell types, but not RHO, contributes to beta-3-mediated adhesion, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils, to a lesser extent, to a lesser extent, Exchange factor for GTP-binding proteins RhoA
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetVAV3 Conjugated
Short name Conjugated, VAV3 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, vav 3 guanine nucleotide exchange factor (Antibody to)
Alternative techniqueantibodies
Alternative to gene target Plasma membranes, VAV3 and IDBG-100649 and ENSG00000134215 and 10451, VAV3 and IDBG-635847 and ENSBTAG00000031575 and 521961, Vav3 and IDBG-188386 and ENSMUSG00000033721 and 57257, metal ion binding, this GO :0001525 and angiogenesis and biological process this GO :0005070 and SH3/SH2 adaptor activity and molecular function this GO :0005085 and guanyl-nucleotide exchange factor activity and molecular function this GO :0005089 and Rho guanyl-nucleotide exchange factor activity and molecular function this GO :0005096 and GTPase activator activity and molecular function this GO :0005154 and epidermal growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006906 and vesicle fusion and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007596 and blood coagulation and biological process this GO :0009967 and positive regulation of signal transduction and biological process this GO :0016477 and cell migration and biological process this GO :0030031 and cell projection assembly and biological process this GO :0030032 and lamellipodium assembly and biological process this GO :0030168 and platelet activation and biological process this GO :0030593 and neutrophil chemotaxis and biological process this GO :0030676 and Rac guanyl-nucleotide exchange factor activity and molecular function this GO :0030890 and positive regulation of B cell proliferation and biological process this GO :0032314 and regulation of Rac GTPase activity and biological process this GO :0032319 and regulation of Rho GTPase activity and biological process this GO :0032321 and positive regulation of Rho GTPase activity and biological process this GO :0035023 and regulation of Rho protein signal transduction and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038096 and Fc-gamma receptor signaling pathway involved in pha this GO cytosis and biological process this GO :0042493 and response to drug and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043087 and regulation of GTPase activity and biological process this GO :0043547 and positive regulation of GTPase activity and biological process this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0045785 and positive regulation of cell adhesion and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0050853 and B cell receptor signaling pathway and biological process this GO :0051056 and regulation of small GTPase mediated signal transduction and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0097190 and apoptotic signaling pathway and biological process, this GO :0005070: SH3/SH2 adaptor activity, this GO :0005070: SH3/SH2 adaptor activity and also this GO :0005085: guanyl-nucleotide exchange factor activity and also this GO :0005089: Rho guanyl-nucleotide exchange factor activity and also this GO :0005096: GTPase activator activity and also this GO :0005154: epidermal growth factor receptor binding and also this GO :0005515: protein binding and also this GO :0030676: Rac guanyl-nucleotide exchange factor activity and also this GO :0046872: metal ion binding, this GO :0005085: guanyl-nucleotide exchange factor activity, this GO :0005089: Rho guanyl-nucleotide exchange factor activity, this GO :0005096: GTPase activator activity, this GO :0005154: epidermal growth factor receptor binding, this GO :0005515: protein binding, this GO :0030676: Rac guanyl-nucleotide exchange factor activity, this GO :0046872: metal ion binding, vav 3 guanine nucleotide exchange factor
Identity 12659
Gene VAV3
Long gene name vav guanine nucleotide exchange factor 3
Synonyms gene name vav 3 oncogene vav 3 guanine nucleotide exchange factor
Locus 1p13, 3
Discovery year 1999-07-07
GenBank acession AF118886
Entrez gene record 10451
RefSeq identity NM_006113
Classification Rho guanine nucleotide exchange factors Pleckstrin homology domain containing SH2 domain containing
Havana BLAST/BLAT OTTHUMG00000010995

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