| Long name | VDAC1 Primary Polyclonal Antibody |
| Also known as | VDAC1 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | VDAC |
| Specificity | May detect VDAC2 due to sequence similarity, This is a highly specific antibody against VDAC |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 95-130/283 |
| Subcellular location | Mitochondrion |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human VDAC1 |
| Gene ID number | 7416 |
| Swiss Prot | P21796 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV, May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis, The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules, The open state has a weak anion selectivity whereas the closed state is cation-selective, in the plasma membrane it is involved in cell volume regulation and apoptosis, Forms a channel through the mitochondrial outer membrane and also the plasma membrane |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM, VDAC, VDAC-1, VDAC1, Voltage-dependent anion-selective channel protein 1, hVDAC1, PORIN |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | VDAC1 |
| Short name | VDAC1 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | voltage-dependent anion channel 1 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | PORIN and VDAC-1, VDAC1 and IDBG-240337 and ENSG00000213585 and 7416, VDAC1 and IDBG-645740 and ENSBTAG00000013113 and 282119, Vdac1 and IDBG-171107 and ENSMUSG00000020402 and 22333, nuclei, porin activity, this GO :0001662 and behavioral fear response and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005743 and mitochondrial inner membrane and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006820 and anion transport and biological process this GO :0006915 and apoptotic process and biological process this GO :0007268 and synaptic transmission and biological process this GO :0007270 and neuron-neuron synaptic transmission and biological process this GO :0007612 and learning and biological process this GO :0008308 and voltage-gated anion channel activity and molecular function this GO :0015288 and porin activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016032 and viral process and biological process this GO :0030855 and epithelial cell differentiation and biological process this GO :0042645 and mitochondrial nucleoid and cellular component this GO :0044070 and regulation of anion transport and biological process this GO :0046930 and pore complex and cellular component this GO :0055085 and transmembrane transport and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0008308: voltage-gated anion channel activity and also this GO :0015288: porin activity, this GO :0008308: voltage-gated anion channel activity, this GO :0015288: porin activity, voltage-dependent anion channel 1 |
| Identity | 12669 |
| Gene | VDAC1 |
| Long gene name | voltage dependent anion channel 1 |
| Synonyms | MGC111064 PORIN |
| Locus | 5q31, 1 |
| Discovery year | 1993-11-02 |
| Entrez gene record | 7416 |
| Pubmed identfication | 7517385 |
| Classification | Voltage dependent anion channels |
| Havana BLAST/BLAT | OTTHUMG00000129118 |
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