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VEGFR1 Antibody

VEGFR1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameVEGFR1 Primary Polyclonal Antibody
Also known asVEGFR1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenVEGFR1
SpecificityThis is a highly specific antibody against VEGFR1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range1160-1210/1333
Subcellular locationCytoplasm
SourceKLH conjugated synthetic peptide derived from rat VEGFR1
Gene ID number54251
Swiss ProtP53767
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, Can promote endothelial cell proliferation, Has very high affinity for VEGFA and relatively low protein kinase activity, Its function in promoting cell proliferation seems to be cell-type specific, Ligand binding leads to the activation of several signaling cascades, MAPK3/ERK1 and the MAP kinase signaling pathway, May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells, Mediates activation of MAPK1/ERK2, Mediates phosphorylation of PIK3R1, Modulates KDR signaling by forming heterodimers with KDR, Phosphorylates SRC, Promotes PGF-mediated proliferation of endothelial cells, Promotes phosphorylation of AKT1 and PTK2/FAK1 (By similarity), VEGFB and PGF, YES1 and PLCG, and cancer cell invasion, and may also phosphorylate CBL, and plays an essential role in the development of embryonic vasculature, and proliferation of some types of cancer cells, as well as of the AKT1 signaling pathway, but does not promote proliferation of normal fibroblasts, cell migration, cell survival, chemotaxis, leading to the activation of phosphatidylinositol kinase and the downstream signaling pathway, macrophage function, may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR, survival and angiogenesis in adulthood, the regulation of angiogenesis, the regulatory subunit of phosphatidylinositol 3-kinase, 4, 5-trisphosphate and the activation of protein kinase C, Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names FLT-1, Flt1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase receptor FLT, Vascular endothelial growth factor receptor 1, Vegfr1, VEGFR-1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetVEGFR1
Short nameVEGFR1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameVEGFR1 (Antibody to)
Alternative techniqueantibodies
Identity 3763
Gene FLT1
Long gene name fms related tyrosine kinase 1
Synonyms gene FLT
Synonyms gene name fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) fms-related tyrosine kinase 1
Synonyms VEGFR1
Synonyms name vascular endothelial growth factor receptor 1 vascular permeability factor receptor
Locus 13q12, 3
Discovery year 1986-01-01
GenBank acession AF063657
Entrez gene record 2321
Pubmed identfication 2158038
RefSeq identity NM_002019
Classification I-set domain containing Immunoglobulin like domain containing Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000016648
Locus Specific Databases The Globin Gene Server LRG_425

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