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VEGFR2(Tyr951) Antibody

VEGFR2(Tyr951) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameVEGFR2(Tyr951) Primary Polyclonal Antibody
Also known asVEGFR2(Tyr951) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenVEGFR2 Tyr951
SpecificityThis is a highly specific antibody against VEGFR2 Tyr951
Modification(s)Phosphorylation
Modification site(s)Tyr951
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range930-970/1356
Subcellular locationIntracellular
SourceKLH cunjugated synthetic phosphopeptide derived from human VEGFR2 around the phosphorylation site of Tyr951
Gene ID number3791
Swiss ProtP35968
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades, Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4, Isoforms lacking a transmembrane domain, MAPK3/ERK1 and the MAP kinase signaling pathway, Mediates activation of MAPK1/ERK2, Mediates phosphorylation of PIK3R1, Modulates FLT1 and FLT4 signaling by forming heterodimers, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC, Phosphorylates PLCG1, Plays an essential role in the regulation of angiogenesis, Promotes phosphorylation of FYN, Promotes proliferation, Promotes reorganization of the actin cytoskeleton, Required for VEGFA-mediated induction of NOS2 and NOS3, VEGFC and VEGFD, VEGFC and/or VEGFD, and embryonic hematopoiesis, as well as of the AKT1 signaling pathway, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells, may function as decoy receptors for VEGFA, migration and differentiation of endothelial cells, reorganization of the actin cytoskeleton and activation of PTK2/FAK1, such as isoform 2 and isoform 3, survival, the regulatory subunit of phosphatidylinositol 3-kinase, vascular development, vascular permeability, 4, 5-trisphosphate and the activation of protein kinase C, Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CD309, FLK-1, Fetal liver kinase 1, KDR, Kinase insert domain receptor, Protein-tyrosine kinase receptor flk-1, VEGFR, VEGFR-2, VEGFR2, Vascular endothelial growth factor receptor 2, FLK1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetVEGFR2(Tyr951)
Short nameVEGFR2(Tyr951) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameVEGFR2(Tyr951) (Antibody to)
Alternative techniqueantibodies
Identity 6307
Gene KDR
Long gene name kinase insert domain receptor
Synonyms gene name kinase insert domain receptor (a type III receptor tyrosine kinase)
Synonyms FLK1 VEGFR VEGFR2 CD309
Synonyms name vascular endothelial growth factor receptor 2 fetal liver kinase 1
Locus 4q12
Discovery year 1991-07-10
GenBank acession AF035121
Entrez gene record 3791
Pubmed identfication 1417831
Classification I-set domain containing CD molecules V-set domain containing Immunoglobulin like domain containing Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000128734
Locus Specific Databases The Globin Gene Server

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