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VEGFR2(Tyr951) Antibody, FITC Conjugated

VEGFR2(Tyr951) Antibody, FITC Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, VEGFR2(Tyr951) Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenVEGFR2 Tyr951
SpecificityThis is a highly specific antibody against VEGFR2 Tyr951
ModificationPhosphorylation
Modification siteTyr951
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range930-970/1356
Subcellular locationIntracellular
SourceKLH cunjugated synthetic phosphopeptide derived from human VEGFR2 around the phosphorylation site of Tyr951
Gene ID number3791
Swiss ProtP35968
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades, Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4, Isoforms lacking a transmembrane domain, MAPK3/ERK1 and the MAP kinase signaling pathway, Mediates activation of MAPK1/ERK2, Mediates phosphorylation of PIK3R1, Modulates FLT1 and FLT4 signaling by forming heterodimers, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC, Phosphorylates PLCG1, Plays an essential role in the regulation of angiogenesis, Promotes phosphorylation of FYN, Promotes proliferation, Promotes reorganization of the actin cytoskeleton, Required for VEGFA-mediated induction of NOS2 and NOS3, VEGFC and VEGFD, VEGFC and/or VEGFD, and embryonic hematopoiesis, as well as of the AKT1 signaling pathway, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells, may function as decoy receptors for VEGFA, migration and differentiation of endothelial cells, reorganization of the actin cytoskeleton and activation of PTK2/FAK1, such as isoform 2 and isoform 3, survival, the regulatory subunit of phosphatidylinositol 3-kinase, vascular development, vascular permeability, 4, 5-trisphosphate and the activation of protein kinase C, Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Synonyms FLK1 VEGFR VEGFR2 CD309
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetVEGFR2(Tyr951) Conjugated
Short name FITC Conjugated, VEGFR2(Tyr951) Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, VEGFR2(Tyr951) (Antibody to)
Alternative techniqueantibodies
Identity 6307
Gene KDR
Long gene name kinase insert domain receptor
Synonyms gene name kinase insert domain receptor (a type III receptor tyrosine kinase)
Synonyms name vascular endothelial growth factor receptor 2 fetal liver kinase 1
Locus 4q12
Discovery year 1991-07-10
GenBank acession AF035121
Entrez gene record 3791
Pubmed identfication 1417831
Classification I-set domain containing CD molecules V-set domain containing Immunoglobulin like domain containing Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000128734
Locus Specific Databases The Globin Gene Server

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