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VEGFR3 Antibody, PE Conjugated

VEGFR3 Antibody, PE Conjugated size: 0.1ml 368

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 368
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name PE Conjugated, VEGFR3 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationPE
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenVEGFR3
SpecificityThis is a highly specific antibody against VEGFR3
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range910-960/1298
Subcellular locationCytoplasm
SourceKLH conjugated synthetic peptide derived from human VEGFR-3
Gene ID number2324
Swiss ProtP35916
Tested applicationsFCM
Recommended dilutionsFCM(1:20-100)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades, MAPK3/ERK1 signaling pathway, Mediates activation of the MAPK1/ERK2, Mediates phosphorylation of PIK3R1, Modulates KDR signaling by forming heterodimers, Phosphorylates SHC1, Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', Promotes proliferation, Signaling by activated FLT4 leads to enhanced production of VEGFC, The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis, and of AKT1 at 'Ser-473', and of the AKT1 signaling pathway, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development, and regulates angiogenic sprouting, and to a lesser degree VEGFA, because it has a truncated C-terminus and therefore lacks several phosphorylation sites, isoform 2 seems to be less efficient in signal transduction, of MAPK8 and the JUN signaling pathway, survival and migration of endothelial cells, the regulatory subunit of phosphatidylinositol 3-kinase, thereby creating a positive feedback loop that enhances FLT4 signaling, Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission480, 565nm/578nm
Synonyms VEGFR3 PCL
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetVEGFR3 PE Conjugated
Short name PE Conjugated, VEGFR3 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelPE
Alternative name peroxidase coupled, VEGFR3 (Antibody to)
Alternative techniqueantibodies
Identity 3767
Gene FLT4
Long gene name fms related tyrosine kinase 4
Synonyms gene name fms-related tyrosine kinase 4
Locus 5q35, 3
Discovery year 1991-10-25
GenBank acession X68203
Entrez gene record 2324
Pubmed identfication 1319394
Classification I-set domain containing Immunoglobulin like domain containing Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000130931

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