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VHL/HRCA1 Antibody

VHL/HRCA1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameVHL/HRCA1 Primary Polyclonal Antibody
Also known asVHL/HRCA1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenVHL/HRCA1
SpecificityThis is a highly specific antibody against VHL/HRCA1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human VHL
Gene ID number7428
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen A germline mutation of this gene is the basis of familial inheritance of VHL syndrome, Alternatively spliced transcript variants encoding distinct isoforms have been observed, RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein, The protein encoded by this gene is a component of the protein complex that includes elongin B, This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), [provided by RefSeq], and cullin-2, and possesses ubiquitin ligase E3 activity, elongin C, which is a transcription factor that plays a central role in the regulation of gene expression by oxygen, Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Elongin binding protein, G7 protein, HRCA1, Hippel-Lindau disease tumor suppressor VHL, Protein G7, RCA1, VHL, VHL 1, VHL1, VHLH, VHL_HUMAN, Von Hippel Lindau disease tumor suppressor, Von Hippel-Lindau disease tumor suppressor, pVHL, von Hippel Lindau syndrome, von Hippel Lindau tumor suppressor, von Hippel-Lindau disease tumor suppressor isoform 2, von Hippel-Lindau syndrome protein homolog, von Hippel-Lindau tumor suppressor isoform 1, VHL1, Von Hippel Lindau, pVHL
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetVHL/HRCA1
Short nameVHL/HRCA1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name E3 ubiquitin protein ligase/HRCA1 (Antibody to), von Hippel-Lindau tumor suppressor
Alternative techniqueantibodies
Alternative to gene target BT, DNA-templated and biological process this GO :0006508 and proteolysis and biological process this GO :0006950 and response to stress and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0016020 and membrane and cellular component this GO :0016567 and protein ubiquitination and biological process this GO :0019899 and enzyme binding and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0045111 and intermediate filament cytoskeleton and cellular component this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0050821 and protein stabilization and biological process this GO :0061418 and regulation of transcription from RNA polymerase II promoter in response to hypoxia and biological process this GO :0061428 and negative regulation of transcription from RNA polymerase II promoter in response to hypoxia and biological process this GO :0071456 and cellular response to hypoxia and biological process, E3 ubiquitin protein ligase, HRCA1 and pVHL and RCA1 and VHL1, VHL and IDBG-17819 and ENSG00000134086 and 7428, Vhl and IDBG-178105 and ENSMUSG00000033933 and 22346, enzyme binding, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000902 and cell morphogenesis and biological process this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005829 and cytosol and cellular component this GO :0006355 and regulation of transcription, this GO :0004842: ubiquitin-protein transferase activity, this GO :0004842: ubiquitin-protein transferase activity and also this GO :0005515: protein binding and also this GO :0008134: transcription factor binding and also this GO :0019899: enzyme binding, this GO :0005515: protein binding, this GO :0008134: transcription factor binding, this GO :0019899: enzyme binding, 79817 and IDBG-644624 and ENSBTAG00000016101 and 540957, von Hippel-Lindau tumor suppressor
Identity 12687
Gene VHL
Long gene name von Hippel-Lindau tumor suppressor
Synonyms gene name E3 ubiquitin protein ligase , von Hippel-Lindau syndrome von Hippel-Lindau tumor suppressor
Synonyms VHL1
Locus 3p25, 3
Discovery year 1986-01-01
GenBank acession L15409
Entrez gene record 7428
Pubmed identfication 9671762
RefSeq identity NM_000551
Havana BLAST/BLAT OTTHUMG00000128668
Locus Specific Databases UMD Locus Specific Databases LRG_322

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