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WNK1(Thr60) Antibody, Cy7 Conjugated

WNK1(Thr60) Antibody, Cy7 Conjugated size: 0.1ml 368

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 368
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, WNK1(Thr60) Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenWNK1 Thr60
SpecificityThis is a highly specific antibody against WNK1 Thr60
ModificationPhosphorylation
Modification siteThr60
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human WNK1 around the phosphorylation site of Thr60
Gene ID number7465
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background SLC12A3, WNK1 is widely expressed, WNK1 may also play a role in actin cytoskeletal reorganization, WNK4 regulates the activity of the thiazide sensitive Na/Cl cotransporter, an autosomal dominant disease characterized by severe hypertension, and sensitivity to thiazide diuretics which may result from a chloride shunt in the renal distal nephron, by phosphorylation, heart, hyperkalemia, kidney and skeletal muscle, potentially by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1, with highest levels observed in the testis, Defects in WNK1 are a cause of pseudohypoaldosteronism type II (PHAII), WNK1 controls sodium and chloride ion transport by inhibiting the activity of WNK4, WNK1 has 4 isoforms produced by alternative splicing
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms HSAN2 PPP1R167
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetWNK1(Thr60) Conjugated
Short name Conjugated, WNK1(Thr60) Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, WNK lysine deficient protein kinase 1(Thr60) (Antibody to)
Alternative techniqueantibodies
Alternative to gene target Cytoplasm, WNK1 and IDBG-11521 and ENSG00000060237 and 65125, WNK1 and IDBG-641017 and ENSBTAG00000005221 and 506433, Wnk1 and IDBG-183036 and ENSMUSG00000045962 and 232341, this GO :0003084 and positive regulation of systemic arterial blood pressure and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004860 and protein kinase inhibitor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0006811 and ion transport and biological process this GO :0010923 and negative regulation of phosphatase activity and biological process this GO :0016772 and transferase activity, this GO :0004672: protein kinase activity, this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0004860: protein kinase inhibitor activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016772: transferase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0004860: protein kinase inhibitor activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016772: transferase activity, this GO :0019869: chloride channel inhibitor activity, this GO :0019902: phosphatase binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019869: chloride channel inhibitor activity and also this GO :0019902: phosphatase binding, transferring phosphorus-containing groups and molecular function this GO :0018107 and peptidyl-threonine phosphorylation and biological process this GO :0019869 and chloride channel inhibitor activity and molecular function this GO :0019902 and phosphatase binding and molecular function this GO :0035556 and intracellular signal transduction and biological process this GO :0048666 and neuron development and biological process this GO :0050794 and regulation of cellular process and biological process this GO :0090188 and negative regulation of pancreatic juice secretion and biological process, WNK lysine deficient protein kinase 1
Identity 14540
Gene WNK1
Long gene name WNK lysine deficient protein kinase 1
Synonyms gene PRKWNK1 HSN2
Synonyms gene name lysine deficient 1 hereditary sensory neuropathy, protein kinase, type II
Synonyms name protein phosphatase 1, regulatory subunit 167
Locus 12p13, 33
Discovery year 2001-02-06
GenBank acession AJ296290
Entrez gene record 65125
RefSeq identity NM_018979
Classification Minor histocompatibility antigens Protein phosphatase 1 regulatory subunits
Havana BLAST/BLAT OTTHUMG00000090321
Locus Specific Databases Inherited Peripheral Neuropathies Mutation Database LRG_247

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