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XAF1 Antibody

XAF1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameXAF1 Primary Polyclonal Antibody
Also known asXAF1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenXAF1
SpecificityThis is a highly specific antibody against XAF1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range170-220/273
Subcellular location Mitochondrion, Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from mouse XAF1
Gene ID number327959
Swiss ProtQ5NBU8
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Rat, Mouse
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen After translocation to mitochondra, Induces cleavage and inactivation of BIRC4 independent of caspase activation, Inhibits anti-caspase activity of BIRC4, May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity), May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway, Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells, Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL, Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria, the process requires the E3 ligase activity of BIRC4, Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names BIRC4-binding protein, Birc4bp, XIAP-associated factor 1, Xaf1, Xiapaf1, Fbox39
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetXAF1
Short nameXAF1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameX-linked inhibitor on apoptosis associated factor 1 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target XAF1 and IDBG-22619 and ENSG00000132530 and 54739, XAF1 and IDBG-633696 and ENSBTAG00000011343 and 509740, Xaf1 and IDBG-196515 and ENSMUSG00000040483 and 327959, nuclei, this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005829 and cytosol and cellular component this GO :0006915 and apoptotic process and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0031333 and negative regulation of protein complex assembly and biological process this GO :0035456 and response to interferon-beta and biological process this GO :0060337 and type I interferon signaling pathway and biological process, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0008270: zinc ion binding, this GO :0008270: zinc ion binding, zinc ion binding, XIAP associated factor 1
Identity 30932
Gene XAF1
Long gene name XIAP associated factor 1
Synonyms BIRC4BP XIAPAF1 HSXIAPAF1
Locus 17p13, 2
Discovery year 2008-03-04
GenBank acession X99699
Entrez gene record 54739
Pubmed identfication 12029096 11175744
RefSeq identity NM_017523
Havana BLAST/BLAT OTTHUMG00000177908

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