XPC Antibody, ALEXA FLUOR 594

XPC Antibody, ALEXA FLUOR 594 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES

Price 332

Size 100ul

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Long name	ALEXA FLUOR 594 Conjugated, XPC Polyclonal Antibody
Also known as	Anti-XPC PAb ALEXA FLUOR 594
Category	Conjugated Primary Antibodies
Conjugated with	594, ALEXA FLUOR®
Host Organism	Rabbit (Oryctolagus cuniculus)
Target Antigen	XPC
Specificity	This is a highly specific antibody against XPC
Modification	Unmodified
Modification Site	None
Clonality	Polyclonal
Clone	Polyclonal antibody
Concentration	1ug per 1ul
Immunogen range	880-920/940
Subcellular location	Nucleus, Cytoplasm
Source	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Xeroderma pigmentosum group C
Gene ID Number	7508
Swiss Prot	Q01831
Tested applications	IF(IHC-P)
Recommended dilutions	IF(IHC-P)(1:50-200)
Crossreactivity	Mouse, Rat, Human
Cross-reactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen	Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation, Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides, Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A, In vitro, Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair, RPA and the TFIIH complex, The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, The orientation of XPC complex binding appears to be crucial for inducing a productive NER, This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity, XPA, XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery, is part of the pre-incision (or initial recognition) complex, it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts, mismatched bubbles or single-stranded overhangs, the XPC:RAD23B dimer is sufficient to initiate NER, Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex
Purification	Purified by Protein A
Storage conditions	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission	590nm/617nm
Synonyms	XPCC RAD4
Properties	ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation	594, ALEXA FLUOR®, Alexa Fluor
Conjugated	Alexa conjugate 1
Gene target	XPC
Short name	XPC Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Label	ALEXA FLUOR 594
Alternative name	ALEXA FLUOR 594, complementation group C (Antibody to), xeroderma pigmentosum
Alternative technique	antibodies
Alternative to gene target	DNA damage recognition and biological process this GO :0000718 and nucleotide-excision repair, DNA damage removal and biological process this GO :0003677 and DNA binding and molecular function this GO :0003684 and damaged DNA binding and molecular function this GO :0003697 and single-stranded DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006281 and DNA repair and biological process this GO :0006289 and nucleotide-excision repair and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0010224 and response to UV-B and biological process this GO :0031573 and intra-S DNA damage checkpoint and biological process this GO :0042493 and response to drug and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071942 and XPC complex and cellular component this GO :1901990 and regulation of mitotic cell cycle phase transition and biological process, XPC and IDBG-19992 and ENSG00000154767 and 7508, XPC and IDBG-646437 and ENSBTAG00000007362 and 524274, Xpc and IDBG-170258 and ENSMUSG00000030094 and 22591, complementation group C, nuclei, p125 and RAD4 and XP3 and XPCC, protein binding, this GO :0000404 and heteroduplex DNA loop binding and molecular function this GO :0000405 and bubble DNA binding and molecular function this GO :0000715 and nucleotide-excision repair, this GO :0000404: heteroduplex DNA loop binding, this GO :0000404: heteroduplex DNA loop binding and also this GO :0000405: bubble DNA binding and also this GO :0003677: DNA binding and also this GO :0003684: damaged DNA binding and also this GO :0003697: single-stranded DNA binding and also this GO :0005515: protein binding, this GO :0000405: bubble DNA binding, this GO :0003677: DNA binding, this GO :0003684: damaged DNA binding, this GO :0003697: single-stranded DNA binding, this GO :0005515: protein binding, xeroderma pigmentosum
Identity	12816
Gene	XPC
Long gene name	DNA damage recognition and repair factor , XPC complex subunit
Synonyms gene name	complementation group C , xeroderma pigmentosum
Synonyms name	xeroderma pigmentosum group C protein
Locus	3p25, 1
Discovery year	1992-10-05
Entrez gene record	7508
Pubmed identfication	1522891
RefSeq identity	NM_004628
Classification	Xeroderma pigmentosum complementation groups
Havana BLAST/BLAT	OTTHUMG00000155526
Locus Specific Databases	LRG_472

XPC Antibody, ALEXA FLUOR 594

XPC Antibody, ALEXA FLUOR 594 size: 100ul 332

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