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YAP1 Antibody

YAP1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameYAP1 Primary Polyclonal Antibody
Also known asYAP1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenYAP1
SpecificityThis is a highly specific antibody against YAP1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range230-280/504
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human YAP1
Gene ID number10413
Swiss ProtP46937
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3), Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, Plays a key role to control cell proliferation in response to cell contact, The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, The presence of TEAD transcription factors are required for it to stimulate gene expression, anchorage-independent growth, and cell migration, and epithelial mesenchymal transition (EMT) induction, cell death, cell growth, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names COB1, Protein yorkie homolog, Transcriptional coactivator YAP1, YAP1, YAP2, YAP65, YKI, Yes-associated protein 1, Yes-associated protein YAP65 homolog, YAP
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetYAP1
Short nameYAP1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameYAP1 (Antibody to)
Alternative techniqueantibodies
Identity 16262
Gene YAP1
Long gene name Yes associated protein 1
Synonyms gene name 65kDa , Yes-associated protein 1
Synonyms YAP65
Locus 11q22, 1
Discovery year 2001-07-17
Entrez gene record 10413
Pubmed identfication 7782338
RefSeq identity NM_006106
Havana BLAST/BLAT OTTHUMG00000167322

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