YAP1 Antibody, Biotin Conjugated

YAP1 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1

Price 333

Size 0.1ml

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Long name	Biotin Conjugated, YAP1 Polyclonal Antibody
Category	Conjugated Primary Antibodies
Conjugation	Biotinylated
Host Organism	Rabbit (Oryctolagus cuniculus)
Target Antigen	YAP1
Specificity	This is a highly specific antibody against YAP1
Modification	Unmodified
Modification site	None
Clonality	Polyclonal
Clone	Polyclonal antibody
Concentration	1ug per 1ul
Immunogen_range	230-280/504
Subcellular location	Nucleus, Cytoplasm
Source	KLH conjugated synthetic peptide derived from human YAP1
Gene ID number	10413
Swiss Prot	P46937
Tested applications	IHC-P, WB
Recommended dilutions	IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity	Mouse, Rat, Human
Crossreactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background	Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3), Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, Plays a key role to control cell proliferation in response to cell contact, The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, The presence of TEAD transcription factors are required for it to stimulate gene expression, anchorage-independent growth, and cell migration, and epithelial mesenchymal transition (EMT) induction, cell death, cell growth, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
Purification method	This antibody was purified via Protein A
Storage conditions	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission	N/A
Synonyms	YAP65
Properties	Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target	YAP1 Conjugated
Short name	Conjugated, YAP1 Antibody
Technique	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label	Biotin
Alternative name	biotinilated coupled, YAP1 (Antibody to)
Alternative technique	antibodies
Identity	16262
Gene	YAP1
Long gene name	Yes associated protein 1
Synonyms gene name	65kDa , Yes-associated protein 1
Locus	11q22, 1
Discovery year	2001-07-17
Entrez gene record	10413
Pubmed identfication	7782338
RefSeq identity	NM_006106
Havana BLAST/BLAT	OTTHUMG00000167322

YAP1 Antibody, Biotin Conjugated

YAP1 Antibody, Biotin Conjugated size: 0.1ml 333

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