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YAP1 Antibody, Cy7 Conjugated

YAP1 Antibody, Cy7 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, YAP1 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenYAP1
SpecificityThis is a highly specific antibody against YAP1
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range230-280/504
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from human YAP1
Gene ID number10413
Swiss ProtP46937
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3), Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, Plays a key role to control cell proliferation in response to cell contact, The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, The presence of TEAD transcription factors are required for it to stimulate gene expression, anchorage-independent growth, and cell migration, and epithelial mesenchymal transition (EMT) induction, cell death, cell growth, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms YAP65
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetYAP1 Conjugated
Short name Conjugated, YAP1 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, YAP1 (Antibody to)
Alternative techniqueantibodies
Identity 16262
Gene YAP1
Long gene name Yes associated protein 1
Synonyms gene name 65kDa , Yes-associated protein 1
Locus 11q22, 1
Discovery year 2001-07-17
Entrez gene record 10413
Pubmed identfication 7782338
RefSeq identity NM_006106
Havana BLAST/BLAT OTTHUMG00000167322

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