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YAP1 Antibody (phospho-S127)

YAP1 Antibody (phospho-S127) size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenYAP1 (phospho-S127)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, DB
Recommended dilutionsDot blot: 1:500
NotesTitration of the phospho-YAP antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis phospho-YAP antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P46937
PurityAntigen affinity
Description Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3), Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, Plays a key role to control cell proliferation in response to cell contact, The core of this pathway is composed of a kinase cascade wherein MST1/MST2, The presence of TEAD transcription factors are required for it to stimulate gene expression, anchorage-independent growth, and cell migration, and epithelial mesenchymal transition (EMT) induction, cell death, cell growth, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
ImmunogenThis phospho-YAP antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS127 of human YAP1
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the phospho-YAP antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetYAP1 (phospho-S127)
Short nameYAP1 Antibody (phospho-S127)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameYAP1 (Antibody to) (phosphorilated-S127)
Alternative techniqueantibodies
Identity 16262
Gene YAP1
Long gene name Yes associated protein 1
Synonyms gene name 65kDa , Yes-associated protein 1
Synonyms YAP65
Locus 11q22, 1
Discovery year 2001-07-17
Entrez gene record 10413
Pubmed identfication 7782338
RefSeq identity NM_006106
Havana BLAST/BLAT OTTHUMG00000167322

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