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YY1 (1183CT6.5.23.6) Monoclonal Antibody

YY1 (1183CT6.5.23.6) Monoclonal Antibody size: 0.1ml 211

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 211
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name5, 23, 6) Monoclonal Antibody, YY1 (1183CT6
Also known as5, 23, 6) Monoclonal Antibody, YY1 (1183CT6
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenYY1
SpecificityThis is a highly specific antibody against YY1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number1183CT6, 5, 6, 23
SourcePurified His-tagged YY1 protein was used to produced this monoclonal antibody
Gene ID number7528
Swiss ProtP25490
Tested ApplicationsWB
Recommended dilutionsIHC(1:25)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343), Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions, Binds to the consensus sequence 5'-CCGCCATNTT-3', DNA replication and probably DNA repair, For example, In vitro, Involved in DNA repair, Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression, May play an important role in development and differentiation, Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed, The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, binds to DNA recombination intermediate structures (Holliday junctions), indirect activation or repression via cofactor recruitment, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence, or activation or repression by disruption of binding sites or conformational DNA changes, proposed to target the INO80 complex to YY1-responsive elements, some genes have been shown to contain a longer binding motif allowing enhanced binding, the initial CG dinucleotide can be methylated greatly reducing the binding affinity, Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site
Purification method This antibody is purified through a protein G column, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Delta transcription factor, INO80 complex subunit S, INO80S, NF-E1, Transcriptional repressor protein YY1, UCRBP, YIN-YANG-1, YY-1, YY1, Yin and yang 1, DELTA
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target5, 23, 6) Monoclonal, YY1 (1183CT6
Short name5, 23, 6) Monoclonal Antibody, YY1 (1183CT6
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name5, 23, 6) monoclonal (Antibody to), YY1 (1183CT6
Alternative techniqueantibodies
Identity 12856
Gene YY1
Long gene name YY1 transcription factor
Synonyms NF-E1 DELTA UCRBP YIN-YANG-1 INO80S
Synonyms name INO80 complex subunit S Yin and Yang 1 protein
Locus 14q32, 2
Discovery year 1993-09-17
GenBank acession BC020324
Entrez gene record 7528
Pubmed identfication 1655281 7912122
RefSeq identity NM_003403
Classification INO80 complex Zinc fingers C2H2-type
Havana BLAST/BLAT OTTHUMG00000150479

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