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Zap70 (1484CT290.68.62) Monoclonal Antibody

Zap70 (1484CT290.68.62) Monoclonal Antibody size: 0.1ml 211

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 211
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name62) Monoclonal Antibody, 68, Zap70 (1484CT290
Also known as62) Monoclonal Antibody, 68, Zap70 (1484CT290
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenZap70
SpecificityThis is a highly specific antibody against Zap70
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number1484CT290, 62, 68
SourceThis Zap70 antibody is generated from a mouse immunized with a recombinant protein
Gene ID number22637
Swiss ProtP43404
Tested Applications FCM, IF, WB
Recommended dilutions FC(1:25), IF(1:25) , WB(1:2000)
Cross reactivity Mouse, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Additionally, Contributes also to the development and activation of primary B-lymphocytes, During thymocyte development, Furthermore, In turn, Regulates motility, Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK, Subsequently, T-cell proliferation and differentiation, This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation, Thus, When antigen presenting cells (APC) activate T-cell receptor (TCR), ZAP70 controls cytoskeleton modifications, ZAP70 is also required for TCR-CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative), ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR), a large number of signaling molecules are recruited and ultimately lead to lymphokine production, a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD3Z through ITAM motif at the plasma membrane, adhesion and cytokine expression of mature T-cells, adhesion and mobility of T-lymphocytes, as well as thymocyte development, thus ensuring correct delivery of effectors to the APC, Tyrosine kinase that plays an essential role in regulation of the adaptive immune response
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase, Tyrosine-protein kinase ZAP-70, ZAP-70, Zap70, mrtle, mur, Srk
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target62) Monoclonal, 68, Zap70 (1484CT290
Short name62) Monoclonal Antibody, 68, Zap70 (1484CT290
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name62) monoclonal (Antibody to), 68, zeta-chain (TCR) associated protein kinase 70kDa (1484CT290
Alternative techniqueantibodies

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