| Long name | ZAP70 Primary Polyclonal Antibody |
| Also known as | ZAP70 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | ZAP70 |
| Specificity | This is a highly specific antibody against ZAP70 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ZAP-70 |
| Gene ID number | 7535 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Jul 2008], Lck and Fyn, Mutations in this gene cause selective T-cell defect, This enzyme, This enzyme is also essential for thymocyte development, Two transcript variants that encode different isoforms have been found for this gene, [provided by RefSeq, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells, and it plays a role in T-cell development and lymphocyte activation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, This gene encodes an enzyme belonging to the protein tyrosine kinase family |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | 70 kDa zeta-associated protein, 70 kDa zeta-chain associated protein, SRK, STD, Syk-related tyrosine kinase, TZK, Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase ZAP-70, ZAP 70, ZAP-70=protein tyrosine kinase Syk homolog {SH2-like and C-terminal kinase domains}, ZAP70, ZAP70_HUMAN, zeta-associated protein 70, ZAP-70 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | ZAP70 |
| Short name | ZAP70 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | zeta-chain (TCR) associated protein kinase 70kDa (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | Cell surfaces, SRK and STCD and STD and TZK and ZAP-70, ZAP70 and IDBG-62509 and ENSG00000115085 and 7535, ZAP70 and IDBG-629842 and ENSBTAG00000005892 and 504509, Zap70 and IDBG-145089 and ENSMUSG00000026117 and 22637, this GO :0001772 and immunological synapse and cellular component this GO :0001784 and phosphotyrosine binding and molecular function this GO :0002250 and adaptive immune response and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004715 and non-membrane spanning protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006955 and immune response and biological process this GO :0016772 and transferase activity, this GO :0001784: phosphotyrosine binding, this GO :0001784: phosphotyrosine binding and also this GO :0004672: protein kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0004715: non-membrane spanning protein tyrosine kinase activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016772: transferase activity, this GO :0004672: protein kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0004715: non-membrane spanning protein tyrosine kinase activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016772: transferase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0030217 and T cell differentiation and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0042101 and T cell receptor complex and cellular component this GO :0042110 and T cell activation and biological process this GO :0042113 and B cell activation and biological process this GO :0043366 and beta selection and biological process this GO :0045059 and positive thymic T cell selection and biological process this GO :0045060 and negative thymic T cell selection and biological process this GO :0045061 and thymic T cell selection and biological process this GO :0045121 and membrane raft and cellular component this GO :0045582 and positive regulation of T cell differentiation and biological process this GO :0046638 and positive regulation of alpha-beta T cell differentiation and biological process this GO :0046641 and positive regulation of alpha-beta T cell proliferation and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0050850 and positive regulation of calcium-mediated signaling and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0070489 and T cell aggregation and biological process this GO :0072678 and T cell migration and biological process, zeta-chain (TCR) associated protein kinase 70kDa |
| Identity | 12858 |
| Gene | ZAP70 |
| Long gene name | zeta chain of T-cell receptor associated protein kinase 70 |
| Synonyms gene | SRK |
| Synonyms gene name | zeta-chain (TCR) associated protein kinase (70 kD) zeta-chain (TCR) associated protein kinase 70kDa zeta chain of T cell receptor associated protein kinase 70kDa zeta chain of T cell receptor associated protein kinase 70 |
| Synonyms | ZAP-70 STD |
| Synonyms name | tyrosine-protein kinase ZAP-70 |
| Locus | 2q11, 2 |
| Discovery year | 1995-05-16 |
| GenBank acession | L05148 |
| Entrez gene record | 7535 |
| Pubmed identfication | 1423621 |
| RefSeq identity | NM_001079 |
| Classification | SH2 domain containing |
| Havana BLAST/BLAT | OTTHUMG00000153060 |
| Locus Specific Databases | ZAP70base: Mutation registry for autosomal recessive ZAP70 immunodeficiency LRG_126 |
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