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ABCB11 Antibody

ABCB11 Antibody size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormPurified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenABCB11
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IHC, WB
Recommended dilutionsIHC (Paraffin): 1:50-1:100, Western blot: 1:1000
NotesTitration of the ABCB11 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis ABCB11 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #O95342
PurityPurified
Description ABCB11 is a multifunctional polypeptide with two homologus halves, Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease, Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2), It is expressed predominatly, PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity, Structurally, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes, ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes
ImmunogenA portion of amino acids 1038-1067 from the human protein was used as the immunogen for this ABCB11 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the ABCB11 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetABCB11
Short nameABCB11 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameABCB11 (Antibody to)
Alternative techniqueantibodies
Identity 42
Gene ABCB11
Long gene name ATP binding cassette subfamily B member 11
Synonyms gene BSEP PFIC2
Synonyms gene name member 11 , progressive familial intrahepatic cholestasis 2 bile salt export pump ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms ABC16 SPGP PFIC-2 PGY4
Synonyms name ABC member 16, MDR/TAP subfamily
Locus 2q31, 1
Discovery year 1998-09-25
GenBank acession AF091582
Entrez gene record 8647
Pubmed identfication 9806540
RefSeq identity NM_003742
Classification ATP binding cassette subfamily B
Havana BLAST/BLAT OTTHUMG00000154039
Locus Specific Databases CCHMC-BMI &, UC Hearing Loss Mutation Database

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