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ADAM2 Antibody

ADAM2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameADAM2 Primary Polyclonal Antibody
Also known asADAM2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenADAM2
SpecificityThis is a highly specific antibody against ADAM2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ADAM2
Gene ID number2515
Tested Applications FCM, IF(IHC-P), IHC-P, WB
Recommended dilutions FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen A member of the metalloproteinase family containing disintigrin-like domains (ADAMs), ADAM-2 does not contain the canonical HExxHxxxxxH zinc metalloproteinase motif, ADAM-2 domain structure consists of a signal sequence followed by a propeptide domain, Integrin a6? on the egg surface is thought to dock with a QDECD motif in the disintegrin domain of ADAM-2, Like the other ADAMs, Localized on the surface of sperm, The 716 amino acid form of ADAM-2 has a deletion in the start of the metalloproteinase domain, The longest ADAM-2 message encodes a protein of 735 amino acids, The sequences are coded from intronless genes, The shorter form of 579 amino acids shared the deletion in the MP domain, Three isoforms of ADAM-2 are reported to date, Unlike ADAM-1, a disintegrin domain cysteine-rich domain, a metalloproteinase domain, a transmembrane domain, also known as PH-30?and Fertilin-? was first described as a sperm-egg fusion protein from guinea pig, although there is some controversy about the precise actions the proteins play, an EGF-like domain, and a cytoplasmic domain, and also has a deletion in the cystein-rich domain, and facilitate sperm-egg fusion, and has a predicted mass of 80, and is not thought to be proteolytically active, and there is some speculation that ADAM-1/ADAM-2 heterodimewr initiated ADAM-3 production on the cell surface, relative to the longer form, the ADAM-2 isoforms are thought to form a heterodimer with ADAM-1 (fertilin-a), the function of ADAM-2 is still poorly understood, which differ in the beginning of the metalloproteinase domain and cysteine-rich domain, with a predicted mass of 82, 2 kDa and pI of 5, 5 kDa and a pI of 5, 73, 75, ADAM-2
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ADAM 2, ADAM metallopeptidase domain 2, ADAM2_HUMAN, AI323749, Adam2, CRYN1, CRYN2, CT15, Cancer/testis antigen 15, Disintegrin and metalloproteinase domain-containing protein 2, Fertilin beta, Fertilin subunit beta, Ftnb, PH 30, PH 30b, PH-30, PH30, PH30-beta, Ph30 beta, A disintegrin and metalloproteinase domain 2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetADAM2
Short nameADAM2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameADAM metallopeptidase domain 2 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target ADAM2 and IDBG-18630 and ENSG00000104755 and 2515, ADAM2 and IDBG-629478 and ENSBTAG00000009408 and 281599, Adam2 and IDBG-174827 and ENSMUSG00000022039 and 11495, CRYN1 and CRYN2 and CT15 and FTNB and PH-30b and PH30 and PH30-beta, Extracellular, this GO :0004222 and metalloendopeptidase activity and molecular function this GO :0005178 and integrin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006508 and proteolysis and biological process this GO :0007155 and cell adhesion and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007338 and single fertilization and biological process this GO :0007339 and binding of sperm to zona pellucida and biological process this GO :0007342 and fusion of sperm to egg plasma membrane and biological process this GO :0008237 and metallopeptidase activity and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0008542 and visual learning and biological process this GO :0009986 and cell surface and cellular component this GO :0030534 and adult behavior and biological process this GO :0032504 and multicellular organism reproduction and biological process, this GO :0004222: metalloendopeptidase activity, this GO :0004222: metalloendopeptidase activity and also this GO :0005178: integrin binding and also this GO :0005515: protein binding and also this GO :0008237: metallopeptidase activity and also this GO :0008270: zinc ion binding, this GO :0005178: integrin binding, this GO :0005515: protein binding, this GO :0008237: metallopeptidase activity, this GO :0008270: zinc ion binding, zinc ion binding, ADAM metallopeptidase domain 2
Identity 198
Gene ADAM2
Long gene name ADAM metallopeptidase domain 2
Synonyms gene FTNB
Synonyms gene name fertilin beta
Synonyms PH-30b PH30 CT15
Synonyms name cancer/testis antigen 15
Locus 8p11, 22
Discovery year 1996-10-26
GenBank acession U52370
Entrez gene record 2515
Pubmed identfication 8702389 9070941
RefSeq identity NM_001464
Classification ADAM metallopeptidase domain containing
Havana BLAST/BLAT OTTHUMG00000164041

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